Wyszukano: ENZO LIFE SCIENCES

Numer katalogowy: (ENZOADI905665100)

Producent: ENZO LIFE SCIENCES

Opis: The Src homology 2 domain containing (Shc) adaptor protein links growth factor, cytokine, and antigen receptor stimulation to the Ras signaling pathway, and plays a critical role in insulin signaling, tumorigenesis, and hematopoietic cell growth and differentiation. Structurally, Shc is composed of an N-terminal phosphotyrosine binding (PTB) domain, a medial CH1 domain, and a C-terminal SH2 domain. Upon binding to activate cell-surface receptors, Shc is phosphorylated at three tyrosine residues (Tyr239, Tyr240, Tyr317) triggering recognition of Shc by SH2-containing proteins such as Grb2.

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOADI905763100)

Producent: ENZO LIFE SCIENCES

Opis: The enzymatic conversion of arginine to citrulline by nitric oxide synthase (NO Synthase) leads to the formation of nitric oxide (NO). Peroxynitrite is formed following reaction of NO with superoxide, producing a potent oxidant that reacts with a variety of biological molecules, including tyrosine residues in proteins. Tyrosine nitration can inactivate enzymes and receptors that depend on tyrosine residues for their activity. Nitration prevents phosphorylation of tyrosine residues important for signal transduction.

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOADI905776100)

Producent: ENZO LIFE SCIENCES

Opis: Cyclins are a family of proteins which function as the regulatory subunits of cyclin/cyclin-dependent kinase (Cdk) holoenzymes, mediating entry into and progression through the cell cycle. Each cyclin is expressed in a temporal fashion during the cell cycle, partnering with a specific Cdk to activate its protein kinase activity. The most well defined mitotic cyclins are: cyclin D, which partners with cdks 4 and 6 during early G1 phase; cyclin E, which activates Cdk2 in the G1 to S phase transition; cyclin A, which utilizes Cdks 1 and 2 during progression through S phase and into G2; and cyclin B, which activates Cdk1 in M-phase promotion.

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOADI9002150001)

Producent: ENZO LIFE SCIENCES

Opis: Rapid, easy-to-use ELISA kit to quantify 25(OH) Vitamin D for bone metabolism, nutrition, endocrinology, immunity and cancer.

j.m.: 1 * 1 KIT

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Numer katalogowy: (ENZOADI900153A0001)

Producent: ENZO LIFE SCIENCES

Opis: The most sensitive, specific and flexible alternative to more costly and time-consuming methods for oxytocin detection.

j.m.: 1 * 1 KIT

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Numer katalogowy: (ENZOADI901014)

Producent: ENZO LIFE SCIENCES

Opis: Most sensitive (0,025 pmol/ml) colorimetric kit for intracellular cGMP quantification.

j.m.: 1 * 1 KIT

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Numer katalogowy: (ENZOADI900158)

Producent: ENZO LIFE SCIENCES

Opis: The Glutathione Peroxidase activity kit is a convenient 96-well plate based assay for the higher throughput analysis of glutathione peroxidase activity in a variety of sample matrices in just 30 minutes.

j.m.: 1 * 1 KIT

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Producent: ENZO LIFE SCIENCES

Opis: The IL-10 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit kor the quantitative determination of human IL-10 in culture supernatants, plasma, and serum.

Numer katalogowy: (ENZOADI905621100)

Producent: ENZO LIFE SCIENCES

Opis: Anthrax Lethal Factor (LF) is a zinc-dependent protease that cleaves mitogen-activated protein kinase kinase (MAPKK) and causes lysis of macrophages. LF, together with Protective Antigen, forms Lethal Toxin, which is the dominant virulence factor produced by B. anthracis and is the major cause of death in infected animals. Lethal toxin has been reported to trigger apoptosis in human melanoma cells.

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOADI905305100)

Producent: ENZO LIFE SCIENCES

Opis: BAFF, or B-cell Activating Factor, is a member of the TNF superfamily also known as BLyS (B Lymphocyte Stimulator), TALL-1 (TNF- and ApoLrelated Leukocyte-expressed Ligand), and THANK (TNF Homologue that Activate Apoptosis, NF-κB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B-cell activator since it induced B-cell proliferation and immunoglobulin secretion. Three receptors for BAFF were identified and designated TACI, BCMA, and BAFF-R. BAFF and its receptors are essential for B-cell development, survival, and humoral immune responses.

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOADI905010100)

Producent: ENZO LIFE SCIENCES

Opis: Progesterone is the major female sex hormone, and is responsible for reproductive-related activities such as breast glandular development, the endometrial aspects of the menstrual cycle, and the establishment and maintenance of pregnancy. In addition, progesterone also directs pregnancy support physiology including changes in carbohydrate, protein and lipid metabolism, thermoregulation, sodium reabsorption in renal tubules and the reduction of alveolar and atrial carbon dioxide partial pressures (PCO2). Progesterone is secreted in large amounts by the corpus luteum and by the extracellular conversion of cholesterol, cholestryl esters, adrenal steroids, prenenolone and pregnenolone sulfate. Small quantities are also secreted directly from the adrenal glands.

j.m.: 1 * 100 µl

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Numer katalogowy: (ENZOADI905185100)

Producent: ENZO LIFE SCIENCES

Opis: Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. In particular, Bnip3L interacts with and overcomes the suppression of apoptosis mediated by Bcl-2 and Bcl-xL.

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOADI905306100)

Producent: ENZO LIFE SCIENCES

Opis: Members of the TNF superfamily regulate immune responses and induce apoptosis. Two members of this family were identified and designated BAFF and April, respectively. Three receptors for BAFF were identified; these include: BCMA (B-cell maturation protein), TACI, and BAFF-R. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B-Cell development and survival, activate NF-κB and c-jun N-terminal kinase, and are involved in B-Cell associated autoimmune diseases.

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOADI905628100)

Producent: ENZO LIFE SCIENCES

Opis: Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages.

j.m.: 1 * 100 µl

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Numer katalogowy: (ENZOADI905638100)

Producent: ENZO LIFE SCIENCES

Opis: Bad is an ~22 kDa pro-apoptotic protein that aids in the initiation of cell death. It exhibits sequence homology to Bcl-2, a protein that prevents apoptosis, within its BH1 and BH2 domains. Bad is phosphorylated at several sites including Ser112, Ser136; phosphorylation by kinases like Akt is known to alter the effects of Bad. Bad has been demonstrated to be phosphorylated at Ser170.

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOBMLP2310001)

Producent: ENZO LIFE SCIENCES

Opis: AMPK substrate

j.m.: 1 * 1 mg

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