Wyszukano: Aflatoxin+B1

Numer katalogowy: (BOSSBS-11749R-FITC)

Producent: Bioss

Opis: In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2Aå and PP2A∫. The PP2A catalytic subunit associates with a variety of regulatory subunits. The B family of regulatory subunits (including B55, B56 and PR72/130 subfamilies) is believed to participate in substrate specificity and catalytic activity. PP2A-B55, also known as PP2A regulatory subunit subfamily B55 or PP2A-B1, is a B subfamily consisting of four B55 isoforms (Alpha,Beta, Gamma and Delta) encoded by four distinct genes.

j.m.: 1 * 100 µl

Wyprzedaż

Numer katalogowy: (USBI123153)

Producent: US Biological

Opis: Anti-AKR1B1 Mouse Monoclonal Antibody [clone: 2D12]

j.m.: 1 * 100 µG

Wyprzedaż

Producent: Merck

Opis: chlorek tiaminy, chlorowodorek, Sigma-Aldrich®

Producent: Merck

Opis: chlorek tiaminy, chlorowodorek, Sigma-Aldrich®

Producent: MOTIC

Opis: Reliable microscopes combined with upgraded optics and robust mechanics to ensure performance.

Numer katalogowy: (BOSSBS-13261R-A555)

Producent: Bioss

Opis: The transcription factor GA-binding protein (GABP) is composed of two subunits, the Ets-related GABP-alpha and a GABP-alpha-associated subunit, GABP beta. GABP alpha binds to a specific DNA sequence and GABP beta exists as b1 and b2 splice variants that differ in their C-termini. In primary neuronal cultures, GABP beta is expressed in both the cytoplasm and the nucleus, whereas GABP alpha is expressed mainly in the nucleus. GABP is constitutively expressed as either a GABP alpha beta heterodimer or a GABP alpha b heterotetramer, both of which can modify GABP-dependent transcription in vitro and in vivo. The GABP alpha beta tetrameric complex performs many different functions, such as stimulating transcription of the adenovirus E4 gene, differentially activating BRCA1 expression in human breast cell lines, potentiating Tat-mediated activation of long terminal repeat promoter transcription and viral replication in certain cell types, acting as a coordinator of mitochrondrial and nuclear transcription for cytochrome oxidase in neurons and assisting in the regulation of rpL32 gene transcription.

j.m.: 1 * 100 µl

Wyprzedaż

Numer katalogowy: (BOSSBS-12484R-FITC)

Producent: Bioss

Opis: Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC’s cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC; thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1.

j.m.: 1 * 100 µl

Wyprzedaż

Producent: MP Biomedicals

Opis: chlorek tiaminy, chlorowodorek, proszek

Numer katalogowy: (USBI039133)

Producent: US Biological

Opis: Anti-NR5A2 Rabbit Polyclonal Antibody

j.m.: 1 * 200 µl

Wyprzedaż

Numer katalogowy: (USBI036633)

Producent: US Biological

Opis: Anti-HMGB1P10 Rabbit Polyclonal Antibody

j.m.: 1 * 200 µl

Wyprzedaż

Numer katalogowy: (USBI042733)

Producent: US Biological

Opis: Anti-TEKT2 Rabbit Polyclonal Antibody

j.m.: 1 * 200 µl

Wyprzedaż

Numer katalogowy: (PRSI56-730)

Producent: ProSci Inc.

Opis: CSN1S1 plays an important role in the capacity of milk to transport calcium phosphate. Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.

j.m.: 1 * 400 µl

New Product Wyprzedaż

Producent: Merck

Opis: chlorek tiaminy, chlorowodorek, Sigma-Aldrich®

Numer katalogowy: (ORIGTA325307)

Producent: OriGene

Opis: Anti-CCNB1 Rabbit Polyclonal Antibody

j.m.: 1 * 100 µl

Wyprzedaż

Numer katalogowy: (BOSSBS-0534R)

Producent: Bioss

Opis: P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.

j.m.: 1 * 100 µl

Wyprzedaż

Numer katalogowy: (BOSSBS-0534R-A488)

Producent: Bioss

Opis: P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.

j.m.: 1 * 100 µl

Wyprzedaż