Wyszukano: 6-Azaspiro[3.4]octan-2-ylmethanol

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WYE-125132 ≥99% (by HPLC)

Producent: ENZO LIFE SCIENCES

Opis: Highly potent, ATP-competitive, and specific mTOR kinase inhibitor. Antiproliferative.

New Product

Perfluorooktan 98%

Numer katalogowy: (APOSPC6140A-5G)

Producent: Apollo Scientific

Opis: Solvent with ability to solubilise molecular oxygen e.g.photooxidation of alkene / epoxidation of alkenes.Synth. Commun., 26, 1861 (1996), ibid 27, 447 (1997).

j.m.: 1 * 5 g

Certyfikaty Wyprzedaż

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octan potasu in aqueous solution USP Test Solution (TS) 34

Numer katalogowy: (85364.260)

Producent: VWR Chemicals

Opis: Ready to use test solutions (TS).

j.m.: 1 * 500 mL

MSDS Certyfikaty Wyprzedaż

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WYE-125132 ≥98%, crystalline solid

Producent: Cayman Chemical

Opis: WYE-125132 is an ATP-competitive inhibitor of mTOR (IC50 = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.