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Image Unavailable-BOSSBS-1975R-A555

Anti-DAXX Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Numer katalogowy: (BOSSBS-1975R-A555)
Producent: Bioss
Opis: Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
j.m.: 1 * 100 µl
Product Image-SORV00186

Akcesroia do wirówek, wolno stojące, Sorvall™ RC3BP™

Producent: Thermo Fisher Scientific
Opis: Centrifuge, floor-standing

Product Image-521-2819

VWR, Akcesoria do mikrowirówek,® cyfrowe

Producent: VWR Collection
Opis: Microcentrifuge, VWR®

Image Unavailable-BOSSBS-1975R-A680

Anti-DAXX Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Numer katalogowy: (BOSSBS-1975R-A680)
Producent: Bioss
Opis: Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilisation. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
j.m.: 1 * 100 µl
Image Unavailable-SORV099-061075

Accessories for Rotors for Sorvall™ LYNX centrifuges

Numer katalogowy: (SORV099-061075)
Producent: Thermo Fisher Scientific
Opis: Rotor lid assembly
j.m.: 1 * 1 SZT
Image Unavailable-171-0683

Akcesoria do systemu wody ultraczystej Millipore, Q-POD

Producent: Merck
Opis: Optimizer LW, 0,1 μm polyethylene final filter for element trace analysis

Image Unavailable-SORV77033

Akcesoria do rotorów do Sorvall® seria RC 12

Producent: Thermo Fisher Scientific
Opis: BIOLink adapter for H-12000 rotor

Image Unavailable-HERA75005759

Akcesoria do Cryofuge® 6000i / 8500i

Producent: Thermo Scientific
Opis: Centrifuge, floor-standing

Product Image-171-0725

System oczyszczania węży, Milli-Q® Integral

Producent: Merck
Opis: The Milli-Q® Integral system is a compact solution that combines the production of Type II (pure) water and Type I (ultrapure) water in a single unit, eliminating the need for a pretreatment stage upstream of the ultrapure water system.

Product Image-111-1553

Zatyczki do uszu na pałąku, E-A-R™ Caboflex™

Producent: 3M
Opis: This lightweight semi-aural hearing protector is ideal when moving in and out of high noise areas, fitting comfortably around the neck when not in use. The conical shaped pods can swivel to align with the ear canal, providing a move resistant seal against noise.

Product Image-171-1379

Systemy oczyszczania wody Milli-Q® IQ 7003/05/10/15

Producent: Merck
Opis: Zintegrowany system wody czystej i ultraczystej, który jest inteligentny, łatwy w użyciu i przyjazny dla środowiska.

Product Image-CTSA11-4134

Części zamienne uszczelek, Sciencix

Numer katalogowy: (CTSA11-4134)
Producent: SCIENCIX
Opis: Replacement parts for OEMs such as Agilent, Shimadzu and Waters chromotograpy systems. Sciencix parts are equivalent to the corresponding OEM part.
j.m.: 1 * 1 SZT
Image Unavailable-521-1812

Akcesoria do wirówki Multifuge® 1

Producent: Thermo Scientific
Opis: Centrifuge, Floor-Standing

Image Unavailable-BOSSBS-8547R

Anti-UEVLD Rabbit Polyclonal Antibody

Numer katalogowy: (BOSSBS-8547R)
Producent: Bioss
Opis: Human papillomaviruses, particularly type 16 (designated HPV16), infect the genital tract and may lead to cervical cancer. Protection against HPV16 is thought to be provided by neutralizing directed to the major caspid protein L1 of HPV16. HPV16 L1 forms the pentameric assembly unit of the viral shell, and the binding of HPV16 L1 to the cell surface without the involvement of minor capsid protein L2 is believed to be the first step of HPV16 infection. The L1-binding domain located near the C-terminus of L2 binds L1 prior to completion of capsid assembly and is required for efficient encapsidation of the viral genome. In addition, the C-terminus of L1 is necessary for both DNA binding and DNA packaging. Expression of the late gene L1 is restricted to the upper layers of the infected epithelium. HPV16 L1 is able to package unrelated plasmid DNA in vitro and deliver the foreign DNA to eukaryotic cells with the subsequent expression of the encoded gene. L1 shows a diffuse nuclear distribution whereas L2 is localized to punctate nuclear regions identified as promonocytic leukemia protein oncogenic domains (PODs). Coexpression of L1 and L2 induces a relocalization of L1 into the PODs.
j.m.: 1 * 100 µl
Image Unavailable-SORV017-0045

Akcesoria do rotorów Fiberlite

Producent: Thermo Fisher Scientific
Opis: Tube removal tool, Do szlifów: Fiberlite™ rotors

New Product

Image Unavailable-PEQL91-PSPIN-RW

Peqlab, Akcesoria do wirówek PerfectSpin

Producent: VWR Peqlab
Opis: Wirnik zabezpieczający do rotora kątowego do probówek 24 × 1,5 ml, Centrifuge, Benchtop

Cena wymaga potwierdzenia u dostawcy
Zapasy tego artykułu są ograniczone, ale możliwe, że jest on dostępny w pobliskim magazynie. Upewnij się, że jesteś zalogowany na stronie, aby móc sprawdzić dostępność zapasów. Jeśli call ciągle się wyświetla i potrzebujesz pomocy, zadzwoń na 58 323 82 00.
Zapasy tego artykułu są ograniczone, ale możliwe, że jest on dostępny w pobliskim magazynie. Upewnij się, że jesteś zalogowany na stronie, aby móc sprawdzić dostępność zapasów. Jeśli call ciągle się wyświetla i potrzebujesz pomocy, zadzwoń na 58 323 82 00.
Ten produkt jest ograniczony w dostępie i można go zamówić tylko przy użyciu zaaprobowanego konta. Jeśli potrzebujesz pomocy, napisz do Działu Prawnego VWR na tomasz.chrobak@pl.vwr.com
Do zakupu tego produktu może być potrzebna dodatkowa dokumentacja. Przedstawiciel VWR skontaktuje się z Tobą w razie potrzeby.
Ten produkt jest zablokowany na stronie internetowej. W celu zamówienia, skontaktuj się z Działem Obsługi Klienta.
Produkt oryginalny został wycofany. Dostępny jest wskazny zamiennik .
Wybrany produkt został wycofany - sprzedaż do wyczerpania zapasów. Dostępne zamienniki można znaleźć poprzez wpisanie powyższego numeru katalogowego VWR w okno wyszukiwarki. Jeśli potrzebujesz dalszej pomocy, prosimy o kontakt z Działem Doradztwa Produktowego pod numerem telefonu 58 3238 220.
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