Wyszukano: odf2

Numer katalogowy: (USBIA0855-43V)

Producent: US Biological

Opis: Anti-ATF2 Rabbit Polyclonal Antibody

j.m.: 1 * 50 µG

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Numer katalogowy: (USBIA0855-42U)

Producent: US Biological

Opis: Anti-ATF2 Rabbit Polyclonal Antibody

j.m.: 1 * 100 µG

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Numer katalogowy: (USBIA0909-42K)

Producent: US Biological

Opis: Anti-ADM2 Rabbit Polyclonal Antibody

j.m.: 1 * 200 µG

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Numer katalogowy: (BOSSBS-0518R)

Producent: Bioss

Opis: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

j.m.: 1 * 100 µl

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Numer katalogowy: (BOSSBS-11703R)

Producent: Bioss

Opis: FMR2 is a 1311 amino acid nuclear protein belonging to the AF4 family. Expressed in the brain, placenta and lung, FMR2 exists as two isoforms produced by alternative splicing. Defects in the gene that encodes FMR2 have been found to be a cause of FRAXE, an X-linked form of mental retardation. Individuals expressing the FRAXE site also have more than two-hundred copies of a GCC repeat adjacent to CpG island, compared to six to thirty-five copies of the GCC repeat in a normal individual. It is believed that loss of FMR2 expression causes this GCC expansion of the FRAXE site.

j.m.: 1 * 100 µl

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Numer katalogowy: (ABNOMAB14484)

Producent: Abnova

Opis: Mouse monoclonal antibody raised against partial recombinant human ADFP.

j.m.: 1 * 100 µG

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Numer katalogowy: (ABNOMAB14486)

Producent: Abnova

Opis: Mouse monoclonal antibody raised against partial recombinant human ADFP.

j.m.: 1 * 100 µG

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Numer katalogowy: (ABNOMAB14741)

Producent: Abnova

Opis: Mouse monoclonal antibody raised against partial recombinant human ADFP.

j.m.: 1 * 100 µG

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Numer katalogowy: (ANTIA278153-100)

Producent: ANTIBODIES.COM

Opis: Mouse monoclonal [PCRP-ATF2-1B4] antibody to ATF2 for Flow Cytometry, IF, IP and WB with samples derived from human.

j.m.: 1 * 100 µG

New Product Wyprzedaż

Numer katalogowy: (ANTIA277565-100)

Producent: ANTIBODIES.COM

Opis: Mouse monoclonal [PCRP-ATF2-1B4] antibody to ATF2 for Flow Cytometry, IF, IP and WB with samples derived from human.

j.m.: 1 * 100 µG

New Product Wyprzedaż

Numer katalogowy: (USBIC2428-43-100)

Producent: US Biological

Opis: Anti-CD72 Rabbit Polyclonal Antibody

j.m.: 1 * 100 µG

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Numer katalogowy: (USBIA0855-42T)

Producent: US Biological

Opis: Anti-ATF2 Rabbit Polyclonal Antibody

j.m.: 1 * 100 µG

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Numer katalogowy: (USBIC2273-17B)

Producent: US Biological

Opis: Anti-CD22 Rabbit Polyclonal Antibody

j.m.: 1 * 100 µG

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Numer katalogowy: (BWRLBS7860)

Producent: Bioworld Technology

Opis: Recombinant full length Human CD22.

j.m.: 1 * 100 µG

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Numer katalogowy: (USBI144314)

Producent: US Biological

Opis: Anti-CD22 Rabbit Polyclonal Antibody

j.m.: 1 * 100 µG

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Numer katalogowy: (BOSSBS-5169R)

Producent: Bioss

Opis: ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

j.m.: 1 * 100 µl

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