Wyszukano: Rhodium(II)+acetate+dimer+dihydrate

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Chlorek miedzi(II) dihydrat 99+% ACS

Producent: Thermo Fisher Scientific

Opis: Chlorek miedzi(II) dihydrat 99+% ACS

MSDS

chlorek cyny (II) dihydrat 98+% ACS

Producent: Thermo Fisher Scientific

Opis: chlorek cyny (II) dihydrat 98+% ACS

MSDS

Anti-TGF beta Receptor 1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Numer katalogowy: (BOSSBS-0638R-A680)

Producent: Bioss

Opis: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

j.m.: 1 * 100 µl

Wyprzedaż

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chlorek cyny (II) dihydrat, czysty reagent analityczny

Producent: CHEMPUR

Opis: chlorek cyny (II) dihydrat, czysty reagent analityczny

chlorek cyny (II) dihydrat USP

Producent: Spectrum Chemical

Opis: chlorek cyny (II) dihydrat USP

chlorek cyny (II) dihydrat do atomowej spektrometrii absorpcyjnej niska zawartość rtęci

Producent: Thermo Fisher Scientific

Opis: chlorek cyny (II) dihydrat for atomic absorption spectroscopy low in mercury

chlorek cyny (II) dihydrat, EMSURE® for analysis (max. 0,000001% Hg), Supelco®

Producent: Merck

Opis: chlorek cyny (II) dihydrat, EMSURE® for analysis (max. 0,000001% Hg), Supelco®

MSDS Certyfikaty

Chlorek miedzi(II) dihydrat ≥99%

Producent: Thermo Fisher Scientific

Opis: Chlorek miedzi(II) dihydrat ≥99%

MSDS Certyfikaty

Anti-JAK2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Numer katalogowy: (BOSSBS-0908R-A750)

Producent: Bioss

Opis: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.

j.m.: 1 * 100 µl

Wyprzedaż