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Bismuth(III) nitrate, hydrate ≥99.999% (metals basis), Puratronic®

Producent: Thermo Fisher Scientific
Opis: It is used in electronic ceramics and fluorescent paints. It is employed as an oxidant for selective oxidation of sulfides to sulfoxides, as a nitrating reagent for synthesizing nitro aromatic compounds, and as a precursor for Dragendorff reagent for use in TLC stain and for testing the presence of alkaloids. On silica gel support, it has been reported to be an efficient catalyst for the Biginelli reaction.

MSDS Certyfikaty

Image Unavailable-ENZOBMLEI2310050

5,6-Dichlorobenzimidazole-1-β-D-Ribofuranoside ≥97% (by TLC)

Numer katalogowy: (ENZOBMLEI2310050)
Producent: ENZO LIFE SCIENCES
Opis: DRB is a potent and specific inhibitor of casein kinase II (CKII, IC50~6 µM). It has been used to inhibit RNA polymerase II mediated-transcription which may be dependent on CKII and its interaction with ATF-1.
j.m.: 1 * 50 mg
Image Unavailable-ENZOALX430049M100

Zinc protoporphyrin ≥95% (by TLC)

Producent: ENZO LIFE SCIENCES
Opis: Potent and selective inhibitor of heme oxygenase (Ki=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter.

Image Unavailable-ENZOBMLEI3690005

Dorsomorphin ≥98% (by TLC)

Producent: ENZO LIFE SCIENCES
Opis: Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.

Image Unavailable-59006.

4-Bromo-A-23187 free acid ≥98% (by TLC, NMR) ionophore, for calcium determination

Numer katalogowy: (59006.)
Producent: Biotium
Opis: Similar to A-23187, 4-Bromo A-23187 is used for in situ calibrations of fluorescent Ca2 indicators to equilibrate intracellular and extracellular calcium concentrations and to allow Mn2 to enter cells to quench indicator fluorescence. However, since 4-bromo A-23187 is nonfluorescent, it is preferred over the blue fluorescent A-23187 for calibrations of UV-excited Ca2 indicators such as Indo-1 and Fura-2 in order to keep background fluorescence to a minimum.
j.m.: 1 * 1 mg
Image Unavailable-ENZOBMLEI3250001

SB-3CT ≥98% (by TLC)

Producent: ENZO LIFE SCIENCES
Opis: Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206µM for MMP-1, 15µM for MMP-3, 96µM for MMP-7, and 4µM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor.

Image Unavailable-ENZOBMLAP3050025

Gambogic acid ≥95% (by TLC)

Producent: ENZO LIFE SCIENCES
Opis: Gambogic Acid is a natural product isolated from Garcinia Hurburyi. It induces apoptosis in several tumor cell lines including T47D breast cancer cells and MGC-803 human gastric carcinoma cells but not in normal cells. Apoptosis induction proceeds via upregulation of bax and inhibition of bcl-2 expression.The target of gambogic acid has been identified as the transferrin receptor.

Image Unavailable-ENZOBMLEI3680010

STAT3 Inhibitor V, Stattic ≥98% (by TLC)

Producent: ENZO LIFE SCIENCES
Opis: Small molecule STAT3-specific inhibitor which blocks activation, dimerization and nuclear translocation via binding to the STAT3 SH2 domain. It is a very useful tool for exploring STAT3-mediated signaling pathways. It blocks LPS-mediated STAT3 tyrosine phosphorylation which leads to inhibition of LPS-mediated IL-1β and IL-6 production. In primary cultures of rat neural stem cells it blocks IL-15-induced differentiation.

Image Unavailable-ENZOBMLGR3600050

Cp 31398 Dihydrochloride (synthetic) ≥98% (by TLC)

Producent: ENZO LIFE SCIENCES
Opis: CP-31398 restores mutant p53 tumor suppressor function in vitro without affecting p53 homologs p63 and p73, and in vivo inhibiting UVB-induced skin carcinogenesis in mice. Stabilization of p53 inhibits ubiquitination without altering phosphorylation at Ser12 or Ser20 or MDM2 binding. Administration of this or similar compounds has the potential to enhance cytotoxic chemotherapy.

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Tricyclodecan-9-yl xanthogenate potassium salt ≥98% (by TLC)

Producent: ENZO LIFE SCIENCES
Opis: Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC). Has been used to study the coupling of phosphatidylcholine-specific phospholipase C with sphingomyelinase. Shows antitumor and antiviral activity. Inhibits basement membrane collagen synthesis, which is the last step in the development of a new blood vessel. Inhibits induction of nitric oxide synthases (NOS). Induces apoptosis. It indirectly inhibits phorbol ester stimulated PLD activity.

Product Image-HAMI80950

Strzykawki do chromatografii cienkowarstwowej

Producent: HAMILTON BONADUZ
Opis: The needle points of these thin layer chromatography syringes are covered with a PTFE coating which reduces the surface tension between the needle and the liquid making it ideal for reproducible sample spotting.

Product Image-ENZOBMLT1090001

Cytochalazyna D (from Zygosporium mansoni) ≥97% (by HPLC, TLC)

Numer katalogowy: (ENZOBMLT1090001)
Producent: ENZO LIFE SCIENCES
Opis: Cytochalasin D is a cell-permeable fungal toxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. It causes the disruption of actin filaments and inhibition of actin polymerization. It is about 10-fold more effective than cytochalasin B and does not inhibit monosaccharide transport across cell membranes. Inactivates low conductance K+ channels. Modulates CD4 cross-linking in T-lymphocytes and increases intracellular Ca2+ levels. Exhibits antitumor activity. Induces apoptosis.
j.m.: 1 * 1 mg
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RG-13022 ≥98% (by TLC)

Numer katalogowy: (ENZOBMLEI2520005)
Producent: ENZO LIFE SCIENCES
Opis: RG-13022 is a non-phenolic tyrphostin analog, which inhibits the EGF receptor (IC50=5 µM) and PDGF receptor tyrosine kinases, and is long-acting. It inhibits EGF-stimulated HER14 cell proliferation (IC50=1 µM) as well as tumor growth in vivo. It inhibits both EGF- and PDGF-stimulated DNA synthesis in human glioma cell lines. RG-13022 is non-phenolic and therefore possesses less antioxidant activity than other tyrphostins.
j.m.: 1 * 5 mg
Image Unavailable-ENZOBMLCA4090050

Xestospongin C ≥90% (by TLC)

Numer katalogowy: (ENZOBMLCA4090050)
Producent: ENZO LIFE SCIENCES
Opis: Xestonspongin C is a structurally novel marine alkaloid isolated from the Okinawan sponge Xestospongia sp. It is a potent, cell-permeable inhibitor of IP3 receptor-mediated Ca²⁺ release (IC50 = 358 nM). However, since xestospongin C also inhibits voltage-dependent Ca²⁺ and K⁺ currents at concentrations similar to those which inhibit the IP3 receptor, it can only be regarded as a selective blocker of the IP3 receptor in permeabilized cells and not in cells with intact plasma membranes. Has vasodilatory properties.
j.m.: 1 * 50 µG
Image Unavailable-ENZOBMLA1650001

Ascomycin (from Streptomyces species) ≥90% (by HPLC, TLC)

Numer katalogowy: (ENZOBMLA1650001)
Producent: ENZO LIFE SCIENCES
Opis: Ascomycin is a close structural analog of FK506 and is a potent immunosuppressant. It binds to FKBP (FK506-binding protein) and suppresses its proline rotamase activity. The ascomycin-FKBP complex inhibits calcineurin, a type 2B phosphatase.
j.m.: 1 * 1 mg
Image Unavailable-ENZOBMLSL1100005

N-Hexanoyl-D-erythro-sphingosine ≥98% (by TLC)

Producent: ENZO LIFE SCIENCES
Opis: A biologically active, cell-permeable, but nonphysiologic ceramide analog. It activates protein phosphatase 2A and MAP kinase (MAPK/ERK), suppresses insulin-induced tyrosine phosphorylation and inhibits glycoprotein traffic by the secretory pathway. It inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. It induces an arrest at the G0/G1 transition of the cell cycle (10μM) and causes apoptosis (15μM or greater) in Molt-4 leukemia cells.

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