Wyszukano: Akt+inhibitor+VIII

Numer katalogowy: (PRSI33-139)

Producent: ProSci Inc.

Opis: HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (alpha and beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIFs regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

j.m.: 1 * 100 µG

New Product Wyprzedaż

Numer katalogowy: (PRSI96-410)

Producent: ProSci Inc.

Opis: Insulin-like growth factor 1 (IGF-1) is also known as somatomedin C, IGF1A, IGFI, sulfation factor, and is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. IGF-1 binds to at least two cell surface receptors: the Insulin-like growth factor 1 receptor, abbreviated as "IGF1R", and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor - it binds IGF-1 at significantly higher affinity than the IGF-1 that is bound to the insulin receptor. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. Its primary action is mediated by binding to its specific receptor IGF1R, present on many cell types in many tissues. Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling; IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death. Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1-6). Specific references are provided for interactions with IGFBP3, IGFBP4 and IGFBP7.

j.m.: 1 * 100 µG

Wyprzedaż

Numer katalogowy: (USBI144373)

Producent: US Biological

Opis: Anti-Coagulation factor VIII Rabbit Polyclonal Antibody

j.m.: 1 * 100 µG

Wyprzedaż

Numer katalogowy: (USBIF0016-10-1)

Producent: US Biological

Opis: Anti-Factor VIII, Human Sheep Polyclonal Antibody

j.m.: 1 * 1 mg

Wyprzedaż

Numer katalogowy: (87047.180)

Producent: VWR Chemicals

Opis: Multi-Element Standard, ICP multi-element standard solution VIII, 24 elements, 100 mg/L each of Al; B; Ba; Be; Bi; Ca; Cd; Co; Cr; Cu; Fe; Ga; K; Li; Mg; Mn; Na; N ; Pb; Se; Sr; Te; Tl; Zn, VWR® ARISTAR®, Matryca: 2% HNO₃, Aplikacja: Wzorce do ICP

j.m.: 1 * 100 mL

MSDS Certyfikaty Wyprzedaż

Producent: VWR Collection

Opis: Acetal polymer. Suitable for holding and identifying large tissue samples in processing, embedding and sectioning procedures. Resistant to all commonly used histological solvents. Mega cassette with welded lid. Box of 100 cassettes.

Numer katalogowy: (USBIV2700-04C)

Producent: US Biological

Opis: Anti-Factor VIII Related Antigen Rabbit Polyclonal Antibody

j.m.: 1 * 1 mL

Wyprzedaż

Producent: Thermo Fisher Scientific

Opis: Tetratlenek osmu 4% (w/w) in water

MSDS

Producent: Thermo Fisher Scientific

Opis: Tetratlenek osmu 2,5% (w/w) in tert-butanol stabilised

MSDS

Numer katalogowy: (USBIN0590-15D)

Producent: US Biological

Opis: Anti-Nei Endonuclease VIII-like 3 Rabbit Polyclonal Antibody

j.m.: 1 * 100 µl

Wyprzedaż

Producent: Thermo Fisher Scientific

Opis: Tetratlenek osmu 4% aqueous solution

MSDS Certyfikaty

Producent: Thermo Fisher Scientific

Opis: Tetratlenek osmu 2% aqueous solution

MSDS Certyfikaty

Numer katalogowy: (BOSSBS-2974R-CY5.5)

Producent: Bioss

Opis: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.

j.m.: 1 * 100 µl

Wyprzedaż

Numer katalogowy: (BOSSBS-0332R-CY3)

Producent: Bioss

Opis: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.

j.m.: 1 * 100 µl

Wyprzedaż

Numer katalogowy: (BOSSBS-0332R-A350)

Producent: Bioss

Opis: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.

j.m.: 1 * 100 µl

Wyprzedaż

Producent: Thermo Fisher Scientific

Opis: Tetratlenek osmu 99.9+% Trace metals basis

MSDS