Wyszukano: 1-Methyl-1,4-cyclohexadiene

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Spectinomycin dihydrochloride pentahydrate

Producent: Apollo Scientific

Opis: An aminocyclitol antibiotic which acts by binding to the 30S subunit of the bacterial ribosome and inhibiting protein synthesis.

Anti-Histone H3 Di Methyl K36 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Numer katalogowy: (BOSSBS-3769R-A750)

Producent: Bioss

Opis: Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.

j.m.: 1 * 100 µl

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Gliotoxin (from Gladiocladium fimbriatum) ≥97% (by HPLC, TLC)

Producent: ENZO LIFE SCIENCES

Opis: Immunomodulating mycotoxin which acts by blocking membrane thiol groups. Inhibits the chymotrypsin-like activity of the 20S proteasome in a non-competitive manner. Causes apoptotic cell death in macrophages and thymocytes. Induces Ca2+ release from intact rat liver mitochondria. Inhibits the activation of transcription factor NF-κB in response to a variety of stimuli in T and B cells. Displays anti-inflammatory activity in vivo. Antioxidant. Inhibitor of farnesyltransferase and geranylgeranyltransferase I. A negative control analog is available. Displays anti-tumor activity against breast cancer in vivo.

Tetrachloro-o-benzochinon

Numer katalogowy: (MOLE73012947-25G)

Producent: Molekula

Opis: Tetrachloro-o-benzochinon

j.m.: 1 * 25 g

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Menadione (2-methyl-1,4-naphthoquinone, vitamin K3) ≥98%, yellow powder

Producent: MP Biomedicals

Opis: Menadione belongs to the Vitamin K class of compounds, which are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione has demonstrated cytotoxic activity against a variety of cell culture lines and can induce apoptosis of cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels.

SB-3CT ≥98% (by TLC)

Producent: ENZO LIFE SCIENCES

Opis: Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206µM for MMP-1, 15µM for MMP-3, 96µM for MMP-7, and 4µM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor.