Necrostatin-1 ≥98% (by TLC)
Dostawca: ENZO LIFE SCIENCES
Inhibits necroptosis
Necrostatin-1 inhibits necroptosis, a non-apoptotic cell death pathway. Inhibits the loss of mitochondrial membrane potential in TNFα-treated Jurkat cells (EC50=490 nM). Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. It displays a pronounced protective effect in a mouse model of ischemic brain injury and inhibits myocardial cell death. Inhibits RIP1 kinase the key upstream kinase involved in the activation of necroptosis (EC50=180nM).
Formuła:
C₁₃H₁₃N₃OS |
Numer MDL:
MFCD00056916 Numer CAS: 4311-88-0 |
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