Sirtinol ≥97% (by NMR)
Dostawca: ENZO LIFE SCIENCES
Synonim:
2-(((2-Hydroxynaphthalen-1-yl)methylene)amino)-N-(1-phenylethyl)benzamide
SIRT inhibitor
Specific cell permeable inhibitor of the sirtuin family of NAD-dependent deacetylases (ySir2: IC50=48µM; hSIRT1: IC50=60µM; hSIRT2: IC50=58µM) with no effect on human HDAC1. Reported to inhibit Sir2p transcriptional silencing activity in vivo (IC50=25µM) and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p (IC50=70µM) and hSIRT2 (IC50=40µM) in vitro.
Formuła:
C₂₆H₂₂N₂O₂ MW: 394.46 g/mol |
Numer MDL:
MFCD00810186 Numer CAS: 410536-97-9 |
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