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Irinotecan hydrochloride trihydrate 98 HPLC_ASSAY_METHOD

Dostawca: ENZO LIFE SCIENCES

Synonim: CPT-11

ALX430139M025
ENZOALX430139M025EA 2760 PLN
ENZOALX430139M025
Irinotecan hydrochloride trihydrate 98 HPLC_ASSAY_METHOD
Irinotecan hydrochloride trihydrate

Topoisomerase I inhibitor


A member of the camptothecin drug family, and an inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication topoisomerase I mediates the relaxation of super coiled DNA, and its inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is, therefore, an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer.

Formuła: C₃₃H₃₈N₄O₆·HCl·3H₂O
MW: 677.19 g/mol (623.15 anhy)
Numer MDL: MFCD01765731
Numer CAS: 136572-09-3

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