Wyszukano: ENZO LIFE SCIENCES

Numer katalogowy: (ENZOALX803335C100)

Producent: ENZO LIFE SCIENCES

Opis: All members of the inhibitor of apoptosis proteins (IAP) family contain at least one, but usually three copies of baculovirus IAP repeat (BIR), a ~70-aa zinc binding domain, and upon overexpression suppress apoptosis. The BIR motif is capable of interacting with caspases and occluding their catalytic pockets. Certain IAPs also possess C-terminal RING domains. RING-containing proteins often act as E3 ubiquitin ligases and can catalyse the degradation of both, themselves and selected target proteins through ubiquitylation. So far, eight human IAPs have been identified: Apollon (Bruce), c-IAP1 (HIAP2; MIHB), c-IAP2 (HIAP1; MIHC), ILP-2 (Ts-IAP), Livin (ML-IAP; KIAP), NAIP, Survivin (TIAP) and XIAP (ILP-1; MIHA). c-IAP1 has been shown to inhibit specific caspases.

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOALX804015C100)

Producent: ENZO LIFE SCIENCES

Opis: The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOALX804077R100)

Producent: ENZO LIFE SCIENCES

Opis: Host: Mouse, Isotype: IgG3

j.m.: 1 * 100 µl

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Numer katalogowy: (ENZOALX804064C100)

Producent: ENZO LIFE SCIENCES

Opis: Host: Mouse, Isotype: IgG1

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOBMLT1090001)

Producent: ENZO LIFE SCIENCES

Opis: Cytochalasin D is a cell-permeable fungal toxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. It causes the disruption of actin filaments and inhibition of actin polymerization. It is about 10-fold more effective than cytochalasin B and does not inhibit monosaccharide transport across cell membranes. Inactivates low conductance K+ channels. Modulates CD4 cross-linking in T-lymphocytes and increases intracellular Ca2+ levels. Exhibits antitumor activity. Induces apoptosis.

j.m.: 1 * 1 mg

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Numer katalogowy: (ENZOADI900165)

Producent: ENZO LIFE SCIENCES

Opis: Most comprehensive portfolio of heat shock protein (chaperone) products commercially available.

j.m.: 1 * 1 KIT

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Numer katalogowy: (ENZOADI900205)

Producent: ENZO LIFE SCIENCES

Opis: The LVV Hemorphin 7 ELISA Kit is a colorimetric, competitive immunoassay kit for the quantitative determination of species independent LVV Hemorphin 7 in serum and tissue homogenate samples.

j.m.: 1 * 1 KIT

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Numer katalogowy: (ENZOADI9002120001)

Producent: ENZO LIFE SCIENCES

Opis: Highly validated, quantitative p62 ELISA kit available for autophagy research.

j.m.: 1 * 1 KIT

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Numer katalogowy: (ENZOADI900204)

Producent: ENZO LIFE SCIENCES

Opis: The Angiotensin II ELISA Kit is a colorimetric, competitive immunoassay kit for the quantitative determination of species independent Angiotensin II in plasma and serum samples.

j.m.: 1 * 1 KIT

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Producent: ENZO LIFE SCIENCES

Opis: Produced in <i>E. coli</i>. Human LC3-I is fused at the N-terminus to a His-tag.

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Numer katalogowy: (ENZOADIAAP149E)

Producent: ENZO LIFE SCIENCES

Opis: The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

j.m.: 1 * 100 µG

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Producent: ENZO LIFE SCIENCES

Opis: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development. Agrin, MuSK, and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation.

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Producent: ENZO LIFE SCIENCES

Opis: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface, and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites, increasing the predicted MW from 200kDa to ~600kDa. The diagram shown indicates the domain structure and functional regions of agrin, as well as domains required for AChR aggregation and alpha-dystroglycan and heparin binding.  Various agrin isoforms are generated by alternative splicing at the X, Y and Z sites, and differ in the presence or absence of small inserts. The isoforms can determine the biological activity of agrin and their expression in specific tissues and stages of development. While no difference in functional activity has been detected between splicing variants at site X, insertion of a 4 aa peptide at site Y modestly increases agrins nAChR clustering activity. Insertion of an 8 aa peptide at splicing site Z increases the clustering activity of soluble rat agrin 10,000 fold.

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Producent: ENZO LIFE SCIENCES

Opis: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development.

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Numer katalogowy: (ENZOBMLUW91900500)

Producent: ENZO LIFE SCIENCES

Opis: Produced in <i>E. coli</i>. Human pro-SUMO-1 is fused at the N-terminus to a His-tag.

j.m.: 1 * 500 µG

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Numer katalogowy: (ENZOBMLVR1040025)

Producent: ENZO LIFE SCIENCES

Opis: Activator of CB1 receptor and TRPV1

j.m.: 1 * 25 mg

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