Wyszukano: Masterflex+Parts

Opis: HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).

Numer katalogowy: ENZOBMLEI2480025

j.m.: 1 * 25 mg

Producent: ENZO LIFE SCIENCES

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Opis: Antibiotic which suppresses nitric oxide (NO) toxicity in pancreatic islet cells. Inhibits protein synthesis by inhibition of elongation factor G at the level of the ribosome.

Numer katalogowy: ENZOALX380011M050

j.m.: 1 * 50 mg

Producent: ENZO LIFE SCIENCES

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Opis: Blocks glucosylation of ceramide by inhibiting UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthetase). Inhibits the expression of cell surface glycolipid antigens and inhibits the growth of cultured rabbit skin fibroblasts. Possesses antitumor activity and inhibits Lewis lung carcinoma cell metastasis in vitro. Useful tool for studying the effects of cellular glycosphingolipid depletion. Enhances the apoptotic response to ionizing radiation by enhancing the ceramide signal.

Numer katalogowy: ENZOBMLSL2100050

j.m.: 1 * 50 mg

Producent: ENZO LIFE SCIENCES

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Opis: 5(6)-SFX (full name: 6-(Fluorescein-5-(and-6)-carboxamido)hexanoic acid,succinimidyl ester) has a 6-atom aminohexanoyl spacer group that separates the fluorescein dye and the amine-reactive group.

Numer katalogowy: 90044.

j.m.: 1 * 10 mg

Producent: Biotium

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Opis: Potent and selective inhibitor of heme oxygenase (Ki=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter.

Numer katalogowy: ENZOALX430049M100

j.m.: 1 * 100 mg

Producent: ENZO LIFE SCIENCES

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Opis: DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.

Numer katalogowy: ENZOBMLEI3470050

j.m.: 1 * 50 mg

Producent: ENZO LIFE SCIENCES

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Opis: PKC substrate.

Numer katalogowy: ENZOBMLPH1070100

j.m.: 1 * 100 µG

Producent: ENZO LIFE SCIENCES

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Opis: Endogenous cannabinoid. Weak ligand of CB1 (Ki=23.8µM) and CB2 (Ki=13.9µM) receptor. Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.1µM). Immunosuppressant, anti-inflammatory, anti-nociceptive and anti-convulsant in vivo. The exact mode of action has not yet been revealed. It has been suggested that PEA: i) binds to a yet to be discovered cannabinoid receptor similar to CB2; ii) administered in vivo elicits the synthesis of endogenous agonists of CB2; iii) acts as an "entourage" compound by enhancing the activity and/or by influencing the turnover of endogenous agonists of CB2, possibly but not uniquely, by inhibiting their degradation.

Numer katalogowy: ENZOBMLFA0180050

j.m.: 1 * 50 mg

Producent: ENZO LIFE SCIENCES

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Opis: HSP90 inhibitor

Numer katalogowy: ENZOBMLEI3080001

j.m.: 1 * 1 mg

Producent: ENZO LIFE SCIENCES

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Opis: Fluorogenic substrate for methionine aminopeptidase 2 (MetAP2) (kcat/Km=1.1 x 10 M-1min-1; Km=310 µM) or aminopeptidase N (Km=377 µM). Ex.: 380 nm, Em.: 460 nm, although the following Ex/Em can also be used: 355,375/440,450. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

Numer katalogowy: ENZOBMLP2360025

j.m.: 1 * 25 mg

Producent: ENZO LIFE SCIENCES

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Opis: Similar to A-23187, 4-Bromo A-23187 is used for in situ calibrations of fluorescent Ca2 indicators to equilibrate intracellular and extracellular calcium concentrations and to allow Mn2 to enter cells to quench indicator fluorescence. However, since 4-bromo A-23187 is nonfluorescent, it is preferred over the blue fluorescent A-23187 for calibrations of UV-excited Ca2 indicators such as Indo-1 and Fura-2 in order to keep background fluorescence to a minimum.

Numer katalogowy: 59006.

j.m.: 1 * 1 mg

Producent: Biotium

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Opis: Xestonspongin C is a structurally novel marine alkaloid isolated from the Okinawan sponge Xestospongia sp. It is a potent, cell-permeable inhibitor of IP3 receptor-mediated Ca²⁺ release (IC50 = 358 nM). However, since xestospongin C also inhibits voltage-dependent Ca²⁺ and K⁺ currents at concentrations similar to those which inhibit the IP3 receptor, it can only be regarded as a selective blocker of the IP3 receptor in permeabilized cells and not in cells with intact plasma membranes. Has vasodilatory properties.

Numer katalogowy: ENZOBMLCA4090050

j.m.: 1 * 50 µG

Producent: ENZO LIFE SCIENCES

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Opis: Disposable glass capillaries for manual sample application of 0,5, 1, 2, 5 or 10 µl. They can be handheld and positioned with the Multipurpose Spotting Guide (551-4230). They can also be used with Universal Capillary Holder (552-0044). Graduated 5 µl glass micropipettes are suitable for qualitative analysis on conventional TLC layers.

Numer katalogowy: 552-0041

j.m.: 1 * 100 SZT

Producent: CAMAG

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Opis: Chromegasphere SI60 Silica HPLC columns are made up of metal free ultra-high purity synthetic silica. TLC solvent systems translate directly to the Chromegasphere SI60 HPLC columns and the high loading capacities permit preparative scale separations.

Numer katalogowy: ESIN135111-S160

j.m.: 1 * 1 SZT

Producent: ES INDUSTRIES

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Opis: Full name: 6-Carboxytetramethylrhodamine succinimidyl ester single isomer. Amine-reactive form ofcarboxytetramethylrhodamine (TAMRA) single isomer.

Numer katalogowy: 90035.

j.m.: 1 * 5 mg

Producent: Biotium

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Opis: TPEN (Tetrakis-(2-pyridylmethyl)ethylenediamine) is an excellent heavy metal chelator while it does not affect Ca2 , Mg2 , Na , or K concentrations. Thus, TPEN is a useful tool to identify effects of heavy metals (Zn2 , Fe2 /Fe3 , Cu2 , and Mn2 , etc.) on fluorescent indicators of Ca2 , Mg2 , Na , or K .

Numer katalogowy: 59003.

j.m.: 1 * 100 mg

Producent: Biotium

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