Wyszukano: Thermo+Scientific

Opis: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

Numer katalogowy: BOSSBS-8996R-CY3

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.Tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines.

Numer katalogowy: BOSSBS-7895R-CY3

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Rabbit monoclonal [EP373Y] to CD34 - BSA and Azide free.

Numer katalogowy: ABCAAB198395-100

j.m.: 1 * 100 µG

Producent: Abcam

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Opis: The eukaryotic translation initiation factors (eIFs) regulate translation at the level of messenger RNA engagement by the ribosome. eIF-2alpha promotes the binding of the initiator tRNA to 40S ribosomal subunits, and is a key signaling component of the unfolded protein response (UPR). eIF-4E recruits mRNAs to the eIF4F complex through binding of their 5 N7-methylguanosine cap. eIF-4E binding proteins-1 and -2 are translational repressors, sequestering eIF-4E in conditions of low cellular demand for translation. Their dissociation from eIF-4E is regulated by phosphorylation in response to growth-promoting stimuli.

Numer katalogowy: ENZOADIKAPMA112E

j.m.: 1 * 100 µG

Producent: ENZO LIFE SCIENCES

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Opis: Rabbit monoclonal [EPR3652] to CD14 - BSA and Azide free.

Numer katalogowy: ABCAAB209971-1

j.m.: 1 * 1 mg

Producent: Abcam

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Opis: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Numer katalogowy: BOSSBS-2507R-CY3

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity).

Numer katalogowy: BOSSBS-2038R-CY3

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.

Numer katalogowy: BOSSBS-2446R-CY5.5

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Numer katalogowy: BOSSBS-4298R-CY5.5

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Numer katalogowy: BOSSBS-2518R-CY3

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Cdx1, Cdx2 and Cdx4 are members of the caudal-type homeobox family of genes, which are homologs of the Drosophila “caudal” gene required for anterior-posterior regional identity. The proteins encoded by these genes are transcription factors which play an important role in development by regulating the expression of Hox genes. Hox genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. Cdx4 is a major positive regulator of the expression of all Hox family members. Due to its critical role as a regulator, Cdx4 is a direct target of the canonical Wnt pathway. The loss of Cdx4 can result in the development of an expanded hindbrain, while the overexpression of Cdx4 may cause the hindbrain to lose its distinct segmental features and resemble the spinal cord.

Numer katalogowy: BOSSBS-12301R-CY3

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Numer katalogowy: BOSSBS-0521R-CY5

j.m.: 1 * 100 µl

Producent: Bioss

Wyprzedaż

Opis: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.

Numer katalogowy: BOSSBS-4979R-CY3

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Numer katalogowy: BOSSBS-3597R-CY5.5

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Numer katalogowy: BOSSBS-0633R-CY3

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Rabbit monoclonal [EPR28929-24] to EDC4 - BSA and Azide free.

Numer katalogowy: ABCAAB321985-100UG

j.m.: 1 * 100 µG

Producent: Abcam

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