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Image Unavailable-BOSSBS-8391R-A488

Anti-RNF75 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Numer katalogowy: (BOSSBS-8391R-A488)
Producent: Bioss
Opis: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-8391R-A750

Anti-RNF75 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Numer katalogowy: (BOSSBS-8391R-A750)
Producent: Bioss
Opis: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-8391R-A555

Anti-RNF75 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Numer katalogowy: (BOSSBS-8391R-A555)
Producent: Bioss
Opis: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-8391R-FITC

Anti-RNF75 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Numer katalogowy: (BOSSBS-8391R-FITC)
Producent: Bioss
Opis: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.
j.m.: 1 * 100 µl
Image Unavailable-93832-100MG-F

2-(5-Bromo-2-pyridylazo)-5-[N-propyl-N-(3-sulphopropyl)amino]phenol disodium salt dihydrate (5-Bromo-PAPS) ≥95.0% (by elemental analysis) for spectrophotometric determination of Cu and Co, for the determination of zinc, Supelco®

Numer katalogowy: (93832-100MG-F)
Producent: Merck
Opis: 2-(5-Bromo-2-pyridylazo)-5-[N-propyl-N-(3-sulfopropyl)amino]phenol disodium salt dihydrate may be used as a reagent for the determination of copper and iron by flow injection-catalytic photometric method using serial flow cell.
j.m.: 1 * 100 mg
Product Image-662-2368

Wzorce, kalibracja kuwet LCK, Addista

Producent: Hach
Opis: System for Analytical Quality Assurance (AQA), consisting of one combined standard/spiking solution and two round robin test solutions.

Image Unavailable-PRSI91-985

Human recombinant SOD1 (from E. coli)

Numer katalogowy: (PRSI91-985)
Producent: ProSci Inc.
Opis: Superoxide Dismutase [Cu-Zn] (SOD1) is a soluble cytoplasmic and mitochondrial intermembrane space protein that belongs to the Cu-Zn superoxide dismutase family. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. SOD1 neutralizes supercharged oxygen molecules, which can damage cells if their levels are not controlled. The enzyme protects the cell against dangerous levels of superoxide. Zinc binding promotes dimerization and stabilizes the native form. Mutations in SOD1 cause a form of familial amyotrophic lateral sclerosis. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) which is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis.
j.m.: 1 * 50 µG
Image Unavailable-BOSSBS-0225M

Anti-KLH Mouse Polyclonal Antibody

Numer katalogowy: (BOSSBS-0225M)
Producent: Bioss
Opis: Keyhole limpet hemocyanin is an extremely large, heterogeneous glycosylated protein consisting of subunits with a molecular weight of 350,000 and 390,000 in aggregates with molecular weights of 4,500,000-13,000,000. Each domain of a KLH subunit contains two copper atoms that together bind a single oxygen molecule (O2). When oxygen is bound to hemocyanin, the molecule takes on a distinctive transparent, opalescent blue color. The KLH protein is potently immunogenic yet safe in humans and is therefore highly prized as a vaccine carrier protein. The large and highly glycosylated KLH protein cannot be reproduced synthetically. It is available only as a purified biological product from the Keyhole Limpet Megathura crenulata.Keyhole limpet hemocyanin (KLH) is used extensively as a carrier protein in the production of for research, biotechnology and therapeutic applications. Haptens are substances with a low molecular weight such as peptides, small proteins and drug molecules that are generally not immunogenic and require the aid of a carrier protein to stimulate a response from the immune system in the form of antibody production.[2] KLH is the most widely employed carrier proteins for this purpose. KLH is an effective carrier protein for several reasons. Its large size and numerous epitopes generate a substantial immune response, and abundance of lysine residues for coupling haptens, allows a high hapten:carrier protein ratio increasing the likelihood of generating hapten-specific . In addition, because KLH is derived from the limpet, a gastropod, it is phylogenetically distant from mammalian proteins, thus reducing false positives in immunologically based research techniques in mammalian model organisms.KLH may also be a challenging molecule to work with because of its propensity to aggregate and precipitate. Aggregates remain immunogenic, but limit the ability to conjugate haptens and are difficult to manipulate in the laboratory.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-0225M-A488

Anti-KLH Mouse Polyclonal Antibody (Alexa Fluor® 488)

Numer katalogowy: (BOSSBS-0225M-A488)
Producent: Bioss
Opis: Keyhole limpet hemocyanin is an extremely large, heterogeneous glycosylated protein consisting of subunits with a molecular weight of 350,000 and 390,000 in aggregates with molecular weights of 4,500,000-13,000,000. Each domain of a KLH subunit contains two copper atoms that together bind a single oxygen molecule (O2). When oxygen is bound to hemocyanin, the molecule takes on a distinctive transparent, opalescent blue color. The KLH protein is potently immunogenic yet safe in humans and is therefore highly prized as a vaccine carrier protein. The large and highly glycosylated KLH protein cannot be reproduced synthetically. It is available only as a purified biological product from the Keyhole Limpet Megathura crenulata.Keyhole limpet hemocyanin (KLH) is used extensively as a carrier protein in the production of for research, biotechnology and therapeutic applications. Haptens are substances with a low molecular weight such as peptides, small proteins and drug molecules that are generally not immunogenic and require the aid of a carrier protein to stimulate a response from the immune system in the form of antibody production.[2] KLH is the most widely employed carrier proteins for this purpose. KLH is an effective carrier protein for several reasons. Its large size and numerous epitopes generate a substantial immune response, and abundance of lysine residues for coupling haptens, allows a high hapten:carrier protein ratio increasing the likelihood of generating hapten-specific . In addition, because KLH is derived from the limpet, a gastropod, it is phylogenetically distant from mammalian proteins, thus reducing false positives in immunologically based research techniques in mammalian model organisms.KLH may also be a challenging molecule to work with because of its propensity to aggregate and precipitate. Aggregates remain immunogenic, but limit the ability to conjugate haptens and are difficult to manipulate in the laboratory.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-0225M-HRP

Anti-KLH Mouse Polyclonal Antibody (HRP (Horseradish Peroxidase))

Numer katalogowy: (BOSSBS-0225M-HRP)
Producent: Bioss
Opis: Keyhole limpet hemocyanin is an extremely large, heterogeneous glycosylated protein consisting of subunits with a molecular weight of 350,000 and 390,000 in aggregates with molecular weights of 4,500,000-13,000,000. Each domain of a KLH subunit contains two copper atoms that together bind a single oxygen molecule (O2). When oxygen is bound to hemocyanin, the molecule takes on a distinctive transparent, opalescent blue color. The KLH protein is potently immunogenic yet safe in humans and is therefore highly prized as a vaccine carrier protein. The large and highly glycosylated KLH protein cannot be reproduced synthetically. It is available only as a purified biological product from the Keyhole Limpet Megathura crenulata.Keyhole limpet hemocyanin (KLH) is used extensively as a carrier protein in the production of for research, biotechnology and therapeutic applications. Haptens are substances with a low molecular weight such as peptides, small proteins and drug molecules that are generally not immunogenic and require the aid of a carrier protein to stimulate a response from the immune system in the form of antibody production.[2] KLH is the most widely employed carrier proteins for this purpose. KLH is an effective carrier protein for several reasons. Its large size and numerous epitopes generate a substantial immune response, and abundance of lysine residues for coupling haptens, allows a high hapten:carrier protein ratio increasing the likelihood of generating hapten-specific . In addition, because KLH is derived from the limpet, a gastropod, it is phylogenetically distant from mammalian proteins, thus reducing false positives in immunologically based research techniques in mammalian model organisms.KLH may also be a challenging molecule to work with because of its propensity to aggregate and precipitate. Aggregates remain immunogenic, but limit the ability to conjugate haptens and are difficult to manipulate in the laboratory.
j.m.: 1 * 100 µl
Image Unavailable-PERCN3050605

Bezelektrodowe lampy wyładowcze

Producent: PerkinElmer
Opis: These electrodeless discharge lamps are preferred for certain volatile elements. They offer better precision and lower detection limits for analyses that are 'noisy' due to weak hollow cathode emission. PerkinElmer system 2 EDLs consist of the element or a salt of the element sealed in a quartz bulb containing an inert gas atmosphere. When an RF field of sufficient power is applied, the inert gas is ionised and the coupled energy vaporizes the element and excites the atoms inside the bulb, resulting in the emission of the characteristic spectrum.

Image Unavailable-PRSI91-588

Human recombinant S100 calcium binding A12 (from E. coli)

Numer katalogowy: (PRSI91-588)
Producent: ProSci Inc.
Opis: Human EN-RAGE belongs to the S100/calgranulin superfamily. There are at least 21 different S100 proteins and the protein is 100% soluble in ammonium sulfate at neutral pH. S100 proteins play a role in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.Human EN-RAGE is characterized by two EF-hand calcium-binding motifs, zinc- and copper-binding protein.S100A12 is a disulfide-linked homodimer and the interface between the two subunits is composed mostly of hydrophobic residues.Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. EN-RAGE acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also acts as a monocyte and mast cell chemoattractant. Moreover, it can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. It can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+from their active sites.
j.m.: 1 * 50 µG
Product Image-5761.5000

Copper (II) ethylenediamine 1 mol/l, VOLUSOL®

Numer katalogowy: (5761.5000)
Producent: VWR Chemicals
Opis: Copper (II) ethylenediamine 1 mol/l, VOLUSOL®
j.m.: 1 * 5 L

MSDS Certyfikaty


Product Image-87204.360

Copper sulphate solution

Numer katalogowy: (87204.360)
Producent: VWR Chemicals
Opis: Copper sulphate solution
j.m.: 1 * 5 L

MSDS Certyfikaty


Product Image-24991.290

Copper (II) ethylenediamine complex 1 mol/l (3 N) in aqueous solution, TECHNICAL

Numer katalogowy: (24991.290)
Producent: VWR Chemicals
Opis: Copper (II) ethylenediamine complex 1 mol/l (3 N) in aqueous solution, TECHNICAL
j.m.: 1 * 1 L

MSDS Certyfikaty


Product Image-87807.290

Copper edetate solution Reag. Ph. Eur. 1022300

Numer katalogowy: (87807.290)
Producent: VWR Chemicals
Opis: Starting materials: Copper acetate R / Sodium edetate / Water R
j.m.: 1 * 1 L

MSDS Certyfikaty


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