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Image Unavailable-BOSSBS-13095R-A647

Anti-ERCC8 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Numer katalogowy: (BOSSBS-13095R-A647)
Producent: Bioss
Opis: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-13095R-FITC

Anti-ERCC8 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Numer katalogowy: (BOSSBS-13095R-FITC)
Producent: Bioss
Opis: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
j.m.: 1 * 100 µl
Product Image-BKC-04

Optymalizator Buffer™dla optymalnego usieciowania i modyfikacji

Producent: G-Biosciences
Opis: The conjugation and modification reactions used to cross-link proteins or couple labels to proteins, such as biotin, enzymes, and fluorescent dyes, require certain conditions, including pH and chemical composition for optimal conjugation. Many common buffers routinely used in laboratories have an inhibitory effect on conjugation reactions; for example, Tris buffers inhibit coupling to amines.

Image Unavailable-ENZOALX210199R100

Anti-GFP Rabbit Polyclonal Antibody

Numer katalogowy: (ENZOALX210199R100)
Producent: ENZO LIFE SCIENCES
Opis: Green Fluorescent Protein (GFP) is responsible for bioluminescence in the jellyfish Aequorea victoria. This protein has quickly become a powerful research tool for assessing gene expression and subcellular protein distribution in fixed or living cells. GFP is excited by and brightly fluoresces when exposed to UV or blue light. This feature makes it ideal as a marker for use in fluorescence microscopy, cytometry, tagging fusion proteins, and assaying transcriptional regulation from gene promoters in vivo. Numerous GFP variants with enhanced and shifted emission spectra (blue, green, and yellow) have been developed through aa substitutions at specific residues.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-8324R-A350

Anti-SERPINB13 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Numer katalogowy: (BOSSBS-8324R-A350)
Producent: Bioss
Opis: Headpin is a skin-specific, UV-repressible serine proteinase inhibitor (serpin) belonging to the ovalbumin serpin family. Headpin is abundant in the human keratinocyte cell line HaCaT, and in lesional keratinocytes from psoriatic skin. Headpin downregulation occurs in squamous cell carcinoma of the oral cavity and in squamous cell carcinoma cell lines of the head and neck.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-13095R-HRP

Anti-ERCC8 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Numer katalogowy: (BOSSBS-13095R-HRP)
Producent: Bioss
Opis: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-15482R-A750

Anti-hHR23b Rabbit Polyclonal Antibody (ALEXA FLUOR® 750)

Numer katalogowy: (BOSSBS-15482R-A750)
Producent: Bioss
Opis: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-15482R-CY5

Anti-hHR23b Rabbit Polyclonal Antibody (Cy5)

Numer katalogowy: (BOSSBS-15482R-CY5)
Producent: Bioss
Opis: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-6634R-A750

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Numer katalogowy: (BOSSBS-6634R-A750)
Producent: Bioss
Opis: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
j.m.: 1 * 100 µl
Product Image-85548.180

VWR® ARISTAR®, Aluminium Standard Solutions for ICP-MS

Producent: VWR Chemicals
Opis: Wzorce glinu, 1000 mg/L, VWR® ARISTAR®, Glin, Matryca: 2-5% HNO₃, Aplikacja: Wzorce do ICP-MS

MSDS Certyfikaty Wyprzedaż

Image Unavailable-730-1014

Opcjonalne moduły personalizacji, do autoklawów pionowych, FVA/A1

Producent: UVP ULTRA VIOLET PRODUCTS
Opis: Replacement tube, 8 W, 254 nm

Image Unavailable-BOSSBS-7905R-CY3

Anti-BRSK1 Rabbit Polyclonal Antibody (Cy3®)

Numer katalogowy: (BOSSBS-7905R-CY3)
Producent: Bioss
Opis: Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.Tissue specificity: Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-7905R-CY5

Anti-BRSK1 Rabbit Polyclonal Antibody (Cy5®)

Numer katalogowy: (BOSSBS-7905R-CY5)
Producent: Bioss
Opis: Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.Tissue specificity: Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-6421R-CY5.5

Anti-EIF4EBP1 Rabbit Polyclonal Antibody (Cy5.5®)

Numer katalogowy: (BOSSBS-6421R-CY5.5)
Producent: Bioss
Opis: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008].
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-6420R-CY5.5

Anti-EIF4EBP1 Rabbit Polyclonal Antibody (Cy5.5®)

Numer katalogowy: (BOSSBS-6420R-CY5.5)
Producent: Bioss
Opis: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008].
j.m.: 1 * 100 µl
Image Unavailable-59006.

4-Bromo-A-23187 free acid ≥98% (by TLC, NMR) ionophore, for calcium determination

Numer katalogowy: (59006.)
Producent: Biotium
Opis: Similar to A-23187, 4-Bromo A-23187 is used for in situ calibrations of fluorescent Ca2 indicators to equilibrate intracellular and extracellular calcium concentrations and to allow Mn2 to enter cells to quench indicator fluorescence. However, since 4-bromo A-23187 is nonfluorescent, it is preferred over the blue fluorescent A-23187 for calibrations of UV-excited Ca2 indicators such as Indo-1 and Fura-2 in order to keep background fluorescence to a minimum.
j.m.: 1 * 1 mg
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Zapasy tego artykułu są ograniczone, ale możliwe, że jest on dostępny w pobliskim magazynie. Upewnij się, że jesteś zalogowany na stronie, aby móc sprawdzić dostępność zapasów. Jeśli call ciągle się wyświetla i potrzebujesz pomocy, zadzwoń na 58 323 82 00.
Ten produkt jest ograniczony w dostępie i można go zamówić tylko przy użyciu zaaprobowanego konta. Jeśli potrzebujesz pomocy, napisz do Działu Prawnego VWR na tomasz.chrobak@pl.vwr.com
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Wybrany produkt został wycofany - sprzedaż do wyczerpania zapasów. Dostępne zamienniki można znaleźć poprzez wpisanie powyższego numeru katalogowego VWR w okno wyszukiwarki. Jeśli potrzebujesz dalszej pomocy, prosimy o kontakt z Działem Doradztwa Produktowego pod numerem telefonu 58 3238 220.
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