Wyszukano: Tyrphostin+B7

Producent: ENZO LIFE SCIENCES

Opis: Member of the tyrphostin family of tyrosine kinase inhibitors. Selective inhibitor of the PDGF receptor kinase (IC50=20µM) vs. the EGF receptor kinase (IC50=820µM). Inhibits PDGF-induced mitogenesis in human bone marrow fibroblasts.

Producent: Apollo Scientific

Opis: Tyrphostin 1 95%

Numer katalogowy: (ENZOALX270141M025)

Producent: ENZO LIFE SCIENCES

Opis: Tyrphostin AG 527 ≥98% (by HPLC)

j.m.: 1 * 25 mg

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Producent: ENZO LIFE SCIENCES

Opis: Tyrphostin 9 is a selective inhibitor of the PDGF receptor tyrosine kinase (IC50=1.2 µM). It is also a potent (10 nM) uncoupler of oxidative phosphorylation.

Numer katalogowy: (ENZOBMLEI1910010)

Producent: ENZO LIFE SCIENCES

Opis: A potent inhibitor of EGF receptor kinase activity (IC50=35 µM).

j.m.: 1 * 10 mg

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Numer katalogowy: (ENZOBMLEI1870005)

Producent: ENZO LIFE SCIENCES

Opis: A potent inhibitor of EGF receptor kinase activity (IC50=3 µM).

j.m.: 1 * 5 mg

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Numer katalogowy: (APOSBISN0202-5MG)

Producent: Apollo Scientific

Opis: MAPK/ERK Signalling Pathway

j.m.: 1 * 5 mg

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Producent: ENZO LIFE SCIENCES

Opis: An inactive tyrphostin, which may be used as a negative control.

Producent: ENZO LIFE SCIENCES

Opis: Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.

Producent: ENZO LIFE SCIENCES

Opis: AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

Producent: Apollo Scientific

Opis: Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Very weak on PDGF receptor and HER2-NEU kinases (IC50 >100 uM). Eur. J. Biochem. 225: 1047-1053 (1994).

Numer katalogowy: (ENZOBMLEI1890005)

Producent: ENZO LIFE SCIENCES

Opis: A potent inhibitor of EGF receptor kinase activity (IC50=0.8 µM). Inhibition is mixed competitive with ATP and substrate.

j.m.: 1 * 5 mg

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Producent: ENZO LIFE SCIENCES

Opis: AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

Numer katalogowy: (ENZOALX270035M005)

Producent: ENZO LIFE SCIENCES

Opis: Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.

j.m.: 1 * 5 mg

Wyprzedaż

Numer katalogowy: (ENZOALX270036M005)

Producent: ENZO LIFE SCIENCES

Opis: EGFR inhibitor

j.m.: 1 * 5 mg

Wyprzedaż

Producent: ENZO LIFE SCIENCES

Opis: A potent inhibitor of PDGF receptor tyrosine kinase (IC50=1 µM). Also inhibits FGF receptor tyrosine kinase and c-kit. Induces apoptosis in a small-cell lung cancer cell line (H526).