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Opis: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration.
Numer katalogowy: BOSSBS-10226R
j.m.: 1 * 100 µl
Producent: Bioss


Opis: Touch-free dispenser for PURELL® hand sanitisers.
Numer katalogowy: 115-1526
j.m.: 1 * 1 SZT
Producent: GOJO Industries - Europe Ltd


Opis: Qlicksmart SnapIT is a simply safer way to open glass ampoules and avoid painful and dangerous sharps injuries. This easy-to-use multi-use ampoule opener avoids the unacceptable sharps injury rates seen when ampoules are opened by hand. L×W: 80×13 mm, 11 g. Plastic (body), Silicon (O-ring), Stainless steel (keyring and spring).
Numer katalogowy: SWANSN-02RPP
j.m.: 1 * 1 SZT
Producent: SWANN MORTON

Certyfikaty


Opis: Anti-ARRDC5 Rabbit Polyclonal Antibody (APC (Allophycocyanin))
Numer katalogowy: USBI032104-APC
j.m.: 1 * 200 µl
Producent: US Biological


Opis: Clear acrylic.
Numer katalogowy: 211-0212
j.m.: 1 * 1 SZT
Producent: VWR Collection


Opis: Manual dispensers for GOJO® foam soaps.
Numer katalogowy: 115-0490
j.m.: 1 * 1 SZT
Producent: GOJO Industries - Europe Ltd


Opis: This compact portable multi-parameter instrument enables measurements of pH, conductivity and dissolved oxygen with intelligent digital sensors (IDS). It has a universal measurement channel for different parameters. The robust, waterproof design makes it ideal for measurements in the field and in the laboratory.
Numer katalogowy: 662-2138
j.m.: 1 * 1 SZT
Producent: WTW


Opis: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Numer katalogowy: BOSSBS-5161R-A350
j.m.: 1 * 100 µl
Producent: Bioss


Opis: PP, coloured.
Numer katalogowy: 212-9561
j.m.: 1 * 4 SZT
Producent: Simport Scientific


Opis: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
Numer katalogowy: BOSSBS-7090R-A680
j.m.: 1 * 100 µl
Producent: Bioss


Opis: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
Numer katalogowy: BOSSBS-7090R-A350
j.m.: 1 * 100 µl
Producent: Bioss


Opis: <p>Meet multiple hygiene needs with one system - wide range of soaps and sanitiser refills in foam, liquid, gel or lotion to suit the business and user's needs.</p>
Numer katalogowy: SCAA565200
j.m.: 1 * 1 SZT
Producent: Essity

New Product


Opis: Anti-DOK1 Rabbit Polyclonal Antibody (Biotin)
Numer katalogowy: USBID8080-01K-BIOT
j.m.: 1 * 200 µl
Producent: US Biological


Opis: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Numer katalogowy: BOSSBS-5161R-HRP
j.m.: 1 * 100 µl
Producent: Bioss


Opis: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Numer katalogowy: BOSSBS-5161R-A555
j.m.: 1 * 100 µl
Producent: Bioss


Opis: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Numer katalogowy: BOSSBS-5161R-A488
j.m.: 1 * 100 µl
Producent: Bioss