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Product Image-ENZOBMLP1320500

TACE substrate (fluorogenic)

Numer katalogowy: (ENZOBMLP1320500)
Producent: ENZO LIFE SCIENCES
Opis: Fluorogenic substrate for TACE (ADAM17) (between Ala-Val), as well as MMP-3, MMP-7, MMP-12, and MMP-17, but not for ADAM19, MMP-13, nor MMP-14. Similar substrates are also cleaved by ADAM10, ADAM8 and ADAM9, and MMP-1, -2, and -9. This quenched substrate is useful for TACE inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm, although the following Ex/Em have been used: 320-340/400-420. Also available: OMNIMMP® Fluorogenic Control peptide (BML-P127).
j.m.: 1 * 0,5 mg

New Product


Product Image-PRSI1131

Anti-TACE Rabbit Polyclonal Antibody

Numer katalogowy: (PRSI1131)
Producent: ProSci Inc.
Opis: TACE Antibody: Tumor-necrosis factor-alpha is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-alpha is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-alpha. TNF-alpha converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.
j.m.: 1 * 100 µG

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Product Image-BOCH8374

Naczynia laboratoryjne, bez pokrywki

Producent: BOCHEM
Opis: Stainless steel 18/10.

Product Image-216-1678

Tace laboratoryjne

Producent: P.S. KUNSTSTOFWERKE
Opis: Melamine, white, polished.

Image Unavailable-BOSSBS-10029R

Anti-Nectin 4 Rabbit Polyclonal Antibody

Numer katalogowy: (BOSSBS-10029R)
Producent: Bioss
Opis: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
j.m.: 1 * 100 µl
Image Unavailable-ENZOBMLEI3250001

SB-3CT ≥98% (by TLC)

Producent: ENZO LIFE SCIENCES
Opis: Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206µM for MMP-1, 15µM for MMP-3, 96µM for MMP-7, and 4µM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor.

New Product

Image Unavailable-BOSSBS-10029R-HRP

Anti-NECTIN4 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Numer katalogowy: (BOSSBS-10029R-HRP)
Producent: Bioss
Opis: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
j.m.: 1 * 100 µl
Image Unavailable-ENZOBMLP2280100

TACE substrate II

Numer katalogowy: (ENZOBMLP2280100)
Producent: ENZO LIFE SCIENCES
Opis: Sensitive fluorogenic substrate for TACE (TNFalpha converting enzyme, ADAM17). Also cleaved by ADAM10 and likely other ADAMs and MMPs. The kcat/Km of TACE for this substrate is 7-fold higher than for the same peptide with the Mca-Dpa fluorophore-quencher pair. FAM fluorescence is quenched by the TAMRA group until cleavage separates them. Ex.: 485 nm, Em.: 535 nm, although the following Ex/Em can also be used: 490,494/515,520 nm. This substrate is useful for inhibitor screening, kinetic analysis, and cellular activity assay.
j.m.: 1 * 100 µG

New Product


Image Unavailable-ENZOBMLP1270001

OmniMMP™ fluorogenic control

Numer katalogowy: (ENZOBMLP1270001)
Producent: ENZO LIFE SCIENCES
Opis: Reference peptide for OmniMMPTM fluorogenic substrate (BML-P126) and TACE (ADAM17) fluorogenic substrate (BML-P132). Ex.: 328 nm, Em.: 393 nm.
j.m.: 1 * 1 mg

New Product


Image Unavailable-ENZOADI905249100

Anti-ADAM17 Rabbit Polyclonal Antibody

Numer katalogowy: (ENZOADI905249100)
Producent: ENZO LIFE SCIENCES
Opis: TNF-alpha converting enzyme (TACE) is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), and is responsible for the cleavage of membrane-bound precursor TNF-alpha to its mature, secreted form. TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP).
j.m.: 1 * 100 µG

New Product


Image Unavailable-ENZOBMLAK3100001

Fluorometryczny zestaw do wykrywania leków ADAM17

Numer katalogowy: (ENZOBMLAK3100001)
Producent: ENZO LIFE SCIENCES
Opis: Designed to screen ADAM17 (TACE) inhibitors using a quenched fluorogenic peptide. The ADAM17 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen ADAM17 (TACE) inhibitors using a quenched fluorogenic peptide: Mca-PLAQAV-Dpa-RSSSR-NH2. Mca fluorescence is quenched by the Dpa group until cleavage by proteases separates the two moieties. The assays are performed in a convenient 96-well microplate format. The kit is useful to screen inhibitors of ADAM17, a potential therapeutic target. The compound GM6001 is also included as a prototypic control inhibitor.
j.m.: 1 * 1 KIT

New Product


Product Image-216-0028

Tace laboratoryjne, z obrzeżem

Producent: BOCHEM
Opis: Stainless steel, ¹⁸/₁₀.

Image Unavailable-ENZOBMLP2350001

ADAM Substrate

Numer katalogowy: (ENZOBMLP2350001)
Producent: ENZO LIFE SCIENCES
Opis: Fluorogenic substrate for ADAM8 (kcat/Km = 1,0×105 M-1s-1), ADAM10 (6,2×103), ADAM12 (2,8×105), TACE (TNF-α converting enzyme, ADAM17) (4,3×105), and likely other ADAMs, especially those that cleave TNF-α type sequences. Also efficiently cleaved by MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, and MMP-14. FAM fluorescence is quenched by the Dabcyl group until cleavage separates them. Ex.: 485 nm, Em.: 530 nm. This substrate is useful for inhibitor screening and kinetic analysis.
j.m.: 1 * 1 mg

New Product


Product Image-PRSI1131P

Human TACE peptide (17 aa near C-terminus)

Numer katalogowy: (PRSI1131P)
Producent: ProSci Inc.
Opis: TACE peptide is used for blocking the activity of TACE antibody.
j.m.: 1 * 50 µG
Product Image-AATB13560

Mca-PLAQAV-Dpa-RSSSR-NH2

Numer katalogowy: (AATB13560)
Producent: AAT BIOQUEST
Opis: Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorogenic peptide substrate for detecting tumor necrosis factor-alpha converting enzyme (TACE or ADAM17) and related enzymes such as ADAM8, ADAM9 and ADAM10.
j.m.: 1 * 1 mg
Product Image-PRSI96-350

Human recombinant growth hormone receptor 1 (from HEK293 cells)

Numer katalogowy: (PRSI96-350)
Producent: ProSci Inc.
Opis: Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
j.m.: 1 * 50 µG
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Zapasy tego artykułu są ograniczone, ale możliwe, że jest on dostępny w pobliskim magazynie. Upewnij się, że jesteś zalogowany na stronie, aby móc sprawdzić dostępność zapasów. Jeśli call ciągle się wyświetla i potrzebujesz pomocy, zadzwoń na 58 323 82 00.
Ten produkt jest ograniczony w dostępie i można go zamówić tylko przy użyciu zaaprobowanego konta. Jeśli potrzebujesz pomocy, napisz do Działu Prawnego VWR na tomasz.chrobak@pl.vwr.com
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Produkt oryginalny został wycofany. Dostępny jest wskazny zamiennik .
Wybrany produkt został wycofany - sprzedaż do wyczerpania zapasów. Dostępne zamienniki można znaleźć poprzez wpisanie powyższego numeru katalogowego VWR w okno wyszukiwarki. Jeśli potrzebujesz dalszej pomocy, prosimy o kontakt z Działem Doradztwa Produktowego pod numerem telefonu 58 3238 220.
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