Wyszukano: Dozowniki+butelkowe

Opis: IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.

Numer katalogowy: BOSSBS-2985R-CY7

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Anti-CDX2 Rabbit monoclonal antibody unconjugated [clone: SP54]

Numer katalogowy: ABCAAB101532-500

j.m.: 1 * 500 µl

Producent: Abcam

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Opis: Mouse monoclonal [PCRP-ATF2-1B4] antibody to ATF2 for Flow Cytometry, IF, IP and WB with samples derived from human.

Numer katalogowy: ANTIA277565-100

j.m.: 1 * 100 µG

Producent: ANTIBODIES.COM

New Product Wyprzedaż

Opis: Mouse monoclonal [PCRP-ATF2-1B4] antibody to ATF2 for Flow Cytometry, IF, IP and WB with samples derived from human.

Numer katalogowy: ANTIA278153-100

j.m.: 1 * 100 µG

Producent: ANTIBODIES.COM

New Product Wyprzedaż

Opis: Anti-ADM2 Rabbit Polyclonal Antibody Rhodamine

Numer katalogowy: USBIA0909-42M5

j.m.: 1 * 100 µl

Producent: US Biological

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Opis: Anti-ADM2 Rabbit Polyclonal Antibody (Biotin)

Numer katalogowy: USBIA0909-42J1

j.m.: 1 * 100 µl

Producent: US Biological

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Opis: ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

Numer katalogowy: BOSSBS-5169R-CY3

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

Numer katalogowy: BOSSBS-0518R-CY3

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: FMR2 is a 1311 amino acid nuclear protein belonging to the AF4 family. Expressed in the brain, placenta and lung, FMR2 exists as two isoforms produced by alternative splicing. Defects in the gene that encodes FMR2 have been found to be a cause of FRAXE, an X-linked form of mental retardation. Individuals expressing the FRAXE site also have more than two-hundred copies of a GCC repeat adjacent to CpG island, compared to six to thirty-five copies of the GCC repeat in a normal individual. It is believed that loss of FMR2 expression causes this GCC expansion of the FRAXE site.

Numer katalogowy: BOSSBS-11703R-CY3

j.m.: 1 * 100 µl

Producent: Bioss

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Opis: Anti-CD32B+CD32A+CD32C Rabbit Monoclonal Antibody [clone: EPR6657(2)]

Numer katalogowy: ABCAAB155972-100

j.m.: 1 * 100 µl

Producent: Abcam

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Opis: Anti-CD22 (phospho Y807) Rabbit Monoclonal Antibody [clone: Y505]

Numer katalogowy: ABCAAB32040-1ML

j.m.: 1 * 1 mL

Producent: Abcam

New Product Wyprzedaż

Opis: Anti-CD32B+CD32A+CD32C Rabbit Monoclonal Antibody [clone: EP6243] (Alexa Fluor® 647)

Numer katalogowy: ABCAAB209451-100

j.m.: 1 * 100 µl

Producent: Abcam

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Opis: Anti-Perilipin-2 Rabbit Monoclonal Antibody [clone: EPR3713] (HRP)

Numer katalogowy: ABCAAB201721-100

j.m.: 1 * 100 µl

Producent: Abcam

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Opis: Anti-CD22 Rabbit Polyclonal Antibody

Numer katalogowy: ABCAAB227787-100

j.m.: 1 * 100 µl

Producent: Abcam

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Opis: Anti-BDH2 Rabbit Polyclonal Antibody

Numer katalogowy: ABCAAB254710-100

j.m.: 1 * 100 µl

Producent: Abcam

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Opis: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008].

Numer katalogowy: BOSSBS-5263R

j.m.: 1 * 100 µl

Producent: Bioss

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