Wyszukano: Methotrexate

Producent: ENZO LIFE SCIENCES

Opis: Methotrexate

Producent: Apollo Scientific

Opis: An antineoplastic agent which acts as an antimetaboliteof folic acid.

Numer katalogowy: (PROOMM0040.00)

Producent: LGC Standards PROMOCHEM

Opis: Methotrexate

j.m.: 1 * 500 mg

Wyprzedaż

Numer katalogowy: (PROOICRS0345)

Producent: LGC Standards PROMOCHEM

Opis: Methotrexate

j.m.: 1 * 100 mg

Wyprzedaż

Producent: Merck

Opis: Methotrexate, Sigma-Aldrich®

Producent: Thermo Fisher Scientific

Opis: Methotrexate hydrate 99%

MSDS

Producent: Thermo Fisher Scientific

Opis: Methotrexate

MSDS Certyfikaty

Numer katalogowy: (MOLEM80419974)

Producent: Molekula

Opis: Methotrexate hydrate

j.m.: 1 * 100 mg

Wyprzedaż

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Producent: MP Biomedicals

Opis: Folic Acid antagonist; structurally similar to folic acid. Methotrexate is a mixture of 4-amino-10-methylfolic acid and closely related compounds.

Numer katalogowy: (J66364.MD)

Producent: Thermo Fisher Scientific

Opis: Sodium methotrexate 98.5%

j.m.: 1 * 250 mg

Certyfikaty Wyprzedaż

Producent: Merck

Opis: Methotrexate hydrate, Sigma-Aldrich®

Producent: MP Biomedicals

Opis: Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of enzymes involved in purine metabolism which leads to the accumulation of adenosine or the suppression of intercellular adhesion molecule expression by T cells. Additionally, this compound has been observed to inhibit DHFR.
Methotrexate is used for chemotherapy either alone or in combination with other agents. It is effective for the treatment of a number of cancers including: breast, head and neck, leukemia, lymphoma, lung, osteosarcoma, bladder, and trophoblastic neoplasms. It is also used in treatment of autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It is used to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.
Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, Methotrexate treatment results in the inhibition of DNA and RNA synthesis.

Producent: Merck

Opis: Methotrexate hydrate, Sigma-Aldrich®

Numer katalogowy: (00023.)

Producent: Biotium

Opis: Fluorescein methotrexate is useful for studying anti-metabolite resistance and spontaneous gene amplification. The dye is actively taken up by cells and binds to dihydrofolate reductase (DHFR) quantitatively.

j.m.: 1 * 1 mg

Wyprzedaż

Numer katalogowy: (USBIM3101-01A)

Producent: US Biological

Opis: Anti-Methotrexate Goat Polyclonal Antibody

j.m.: 1 * 100 µl

Wyprzedaż

Numer katalogowy: (USBIM3101-01D)

Producent: US Biological

Opis: Anti-Methotrexate Sheep Polyclonal Antibody

j.m.: 1 * 500 µl

Wyprzedaż