Drukuj

Wyszukano: Kova+International


85 374  wyniki/ów wyszukiwania

Doprecyzuj wyniki Sortuj
SearchResultCount:"85374"

Sort Results

Widok listy Widok uproszczony (nowość)

Oceń wyniki wyszukiwania

Image Unavailable-BOSSBS-5373R

Anti-GIT1 Rabbit Polyclonal Antibody

Numer katalogowy: (BOSSBS-5373R)
Producent: Bioss
Opis: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-13608R-A488

Anti-CEP57 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Numer katalogowy: (BOSSBS-13608R-A488)
Producent: Bioss
Opis: CEP57 (centrosomal protein 57kDa), also known as PIG8, TSP57 or Translokin, is a 500 amino acid protein that localizes to both the nucleus and the cytoplasm, specifically associating with microtubules at the centrosome. Expressed ubiquitously, CEP57 exists as a homodimer that functions to mediate the mitogenic activity and nuclear translocation of FGF-2, an internalized growth factor, thereby regulating FGF-2 signaling pathways. Additionally, CEP57 is thought to play a role in spermatogenesis, possibly via the indirect regulation of gene expression. Human CEP57 shares 88% sequence identity with its mouse and bovine orthologs, suggesting a highly conserved role between species. Multiple isoforms of CEP57 exist due to alternative splicing events.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-13608R-A555

Anti-CEP57 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Numer katalogowy: (BOSSBS-13608R-A555)
Producent: Bioss
Opis: CEP57 (centrosomal protein 57kDa), also known as PIG8, TSP57 or Translokin, is a 500 amino acid protein that localizes to both the nucleus and the cytoplasm, specifically associating with microtubules at the centrosome. Expressed ubiquitously, CEP57 exists as a homodimer that functions to mediate the mitogenic activity and nuclear translocation of FGF-2, an internalized growth factor, thereby regulating FGF-2 signaling pathways. Additionally, CEP57 is thought to play a role in spermatogenesis, possibly via the indirect regulation of gene expression. Human CEP57 shares 88% sequence identity with its mouse and bovine orthologs, suggesting a highly conserved role between species. Multiple isoforms of CEP57 exist due to alternative splicing events.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-5373R-CY5.5

Anti-GIT1 Rabbit Polyclonal Antibody (Cy5.5®)

Numer katalogowy: (BOSSBS-5373R-CY5.5)
Producent: Bioss
Opis: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-12176R-A647

Anti-KCNJ1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Numer katalogowy: (BOSSBS-12176R-A647)
Producent: Bioss
Opis: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-12176R-CY7

Anti-KCNJ1 Rabbit Polyclonal Antibody (Cy7®)

Numer katalogowy: (BOSSBS-12176R-CY7)
Producent: Bioss
Opis: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-12176R-A350

Anti-KCNJ1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Numer katalogowy: (BOSSBS-12176R-A350)
Producent: Bioss
Opis: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-5373R-A647

Anti-GIT1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Numer katalogowy: (BOSSBS-5373R-A647)
Producent: Bioss
Opis: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-13608R-CY5

Anti-CEP57 Rabbit Polyclonal Antibody (Cy5®)

Numer katalogowy: (BOSSBS-13608R-CY5)
Producent: Bioss
Opis: CEP57 (centrosomal protein 57kDa), also known as PIG8, TSP57 or Translokin, is a 500 amino acid protein that localizes to both the nucleus and the cytoplasm, specifically associating with microtubules at the centrosome. Expressed ubiquitously, CEP57 exists as a homodimer that functions to mediate the mitogenic activity and nuclear translocation of FGF-2, an internalized growth factor, thereby regulating FGF-2 signaling pathways. Additionally, CEP57 is thought to play a role in spermatogenesis, possibly via the indirect regulation of gene expression. Human CEP57 shares 88% sequence identity with its mouse and bovine orthologs, suggesting a highly conserved role between species. Multiple isoforms of CEP57 exist due to alternative splicing events.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-5372R-A750

Anti-GIT1 Ser375 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Numer katalogowy: (BOSSBS-5372R-A750)
Producent: Bioss
Opis: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-5373R-A750

Anti-GIT1 Tyr545 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Numer katalogowy: (BOSSBS-5373R-A750)
Producent: Bioss
Opis: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-11334R-A350

Anti-APBA1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Numer katalogowy: (BOSSBS-11334R-A350)
Producent: Bioss
Opis: The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11å (also designated Mint 1), X11Beta (Mint 2) and X11(Mint 3).
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-11334R-A647

Anti-APBA1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Numer katalogowy: (BOSSBS-11334R-A647)
Producent: Bioss
Opis: The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11å (also designated Mint 1), X11Beta (Mint 2) and X11(Mint 3).
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-2960R-A488

Anti-KCNJ1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Numer katalogowy: (BOSSBS-2960R-A488)
Producent: Bioss
Opis: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-2960R-HRP

Anti-KCNJ1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Numer katalogowy: (BOSSBS-2960R-HRP)
Producent: Bioss
Opis: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-8601R

Anti-SLC9A3 Rabbit Polyclonal Antibody

Numer katalogowy: (BOSSBS-8601R)
Producent: Bioss
Opis: NHE-3 are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics. NHE-3 localizes to the apical membrane of renal proximal tubules where it is responsible for most of the sodium transport and fluid reabsorption. NHE-3 translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. NHE-3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells.
j.m.: 1 * 100 µl
Cena wymaga potwierdzenia u dostawcy
Zapasy tego artykułu są ograniczone, ale możliwe, że jest on dostępny w pobliskim magazynie. Upewnij się, że jesteś zalogowany na stronie, aby móc sprawdzić dostępność zapasów. Jeśli call ciągle się wyświetla i potrzebujesz pomocy, zadzwoń na 58 323 82 00.
Zapasy tego artykułu są ograniczone, ale możliwe, że jest on dostępny w pobliskim magazynie. Upewnij się, że jesteś zalogowany na stronie, aby móc sprawdzić dostępność zapasów. Jeśli call ciągle się wyświetla i potrzebujesz pomocy, zadzwoń na 58 323 82 00.
Ten produkt jest ograniczony w dostępie i można go zamówić tylko przy użyciu zaaprobowanego konta. Jeśli potrzebujesz pomocy, napisz do Działu Prawnego VWR na tomasz.chrobak@pl.vwr.com
Do zakupu tego produktu może być potrzebna dodatkowa dokumentacja. Przedstawiciel VWR skontaktuje się z Tobą w razie potrzeby.
Ten produkt jest zablokowany na stronie internetowej. W celu zamówienia, skontaktuj się z Działem Obsługi Klienta.
Produkt oryginalny został wycofany. Dostępny jest wskazny zamiennik .
Wybrany produkt został wycofany - sprzedaż do wyczerpania zapasów. Dostępne zamienniki można znaleźć poprzez wpisanie powyższego numeru katalogowego VWR w okno wyszukiwarki. Jeśli potrzebujesz dalszej pomocy, prosimy o kontakt z Działem Doradztwa Produktowego pod numerem telefonu 58 3238 220.
913 - 928 of 85 374
no targeter for Bottom