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Image Unavailable-ENZOALX270473M002

BIX 01294 trihydrochloride, hydrate ≥95% (by HPLC)

Numer katalogowy: (ENZOALX270473M002)
Producent: ENZO LIFE SCIENCES
Opis: Selective and cell permeable inhibitor of G9a histone methyltransferase.
j.m.: 1 * 2 mg
Image Unavailable-BOSSBS-12864R-CY5

Anti-BTC Rabbit Polyclonal Antibody (Cy5®)

Numer katalogowy: (BOSSBS-12864R-CY5)
Producent: Bioss
Opis: Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, was originally identified as a growth-promoting factor in the conditioned medium of a mouse pancreatic-cell carcinoma (insulinoma) cell line and has since been identified in humans. BTC is synthesized as a large transmembrane precursor molecule that can be cleaved proteolytically to release the soluble form of BTC or function as membrane-anchored growth factors in juxtacrine signaling. BTC, in addition to stimulating homodimers of ErbB-1 and ErbB-4, is capable of binding and activating all possible combinations of heterodimeric ErbB receptors including the oncogenic ErbB-2/ErbB-3 complex. BTC is also expressed in some human malignancies and may have an important role in tumor growth progression.
j.m.: 1 * 100 µl
Product Image-BOHLV1755-08

SICCO Auto Glove Box with Transfer Chamber

Numer katalogowy: (BOHLV1755-08)
Producent: Bohlender
Opis: Designed for the handling of humidity-sensitive products in a dry atmosphere.
j.m.: 1 * 1 SZT
Image Unavailable-BOSSBS-3132R-CY7

Anti-BMX Rabbit Polyclonal Antibody (Cy7®)

Numer katalogowy: (BOSSBS-3132R-CY7)
Producent: Bioss
Opis: This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009].
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-0127M-CY5

Anti-BAX Mouse Polyclonal Antibody (Cy5®)

Numer katalogowy: (BOSSBS-0127M-CY5)
Producent: Bioss
Opis: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-3055R-CY5.5

Anti-BTK Rabbit Polyclonal Antibody (Cy5.5®)

Numer katalogowy: (BOSSBS-3055R-CY5.5)
Producent: Bioss
Opis: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-2752R-CY3

Anti-BTK Rabbit Polyclonal Antibody (Cy3®)

Numer katalogowy: (BOSSBS-2752R-CY3)
Producent: Bioss
Opis: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-12905R-CY7

Anti-BSX Rabbit Polyclonal Antibody (Cy7®)

Numer katalogowy: (BOSSBS-12905R-CY7)
Producent: Bioss
Opis: BSX(Brain-specific homeobox protein homolog) may play a role in the determination and function of cell types in the brain. In brain, it is restricted to a few specific developing brain structures such as pineal gland, telencephalic septum, hypothalamic pre-mammillary body and arcuate nucleus. Bsx might be considered an important molecular marker for early embryonic stages of epiphysis development. It belongs to the distal-less homeobox family and contains 1 homeobox DNA-binding domain.
j.m.: 1 * 100 µl
Product Image-216-6985

Pojemniki chłodzące

Producent: CAMPING GAZ
Opis: Blue-white PP. Sturdy, robust design, ideal for storing and transporting temperature-sensitive materials and samples.

Image Unavailable-BOSSBS-0127R-CY5

Anti-BAX Rabbit Polyclonal Antibody (Cy5®)

Numer katalogowy: (BOSSBS-0127R-CY5)
Producent: Bioss
Opis: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-2765R-CY5.5

Anti-BMX Rabbit Polyclonal Antibody (Cy5.5®)

Numer katalogowy: (BOSSBS-2765R-CY5.5)
Producent: Bioss
Opis: This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009].
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-3069R-CY5.5

Anti-BTK Rabbit Polyclonal Antibody (Cy5.5®)

Numer katalogowy: (BOSSBS-3069R-CY5.5)
Producent: Bioss
Opis: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-5223R-CY5

Anti-BMX Rabbit Polyclonal Antibody (Cy5®)

Numer katalogowy: (BOSSBS-5223R-CY5)
Producent: Bioss
Opis: This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009].
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-0127M-CY5.5

Anti-BAX Mouse Polyclonal Antibody (Cy5.5®)

Numer katalogowy: (BOSSBS-0127M-CY5.5)
Producent: Bioss
Opis: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
j.m.: 1 * 100 µl
Image Unavailable-BOSSBS-0127M-CY3

Anti-BAX Mouse Polyclonal Antibody (Cy3®)

Numer katalogowy: (BOSSBS-0127M-CY3)
Producent: Bioss
Opis: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
j.m.: 1 * 100 µl
Image Unavailable-USBIB0175-04H

Anti-BAX Rabbit polyclonal antibody unconjugated

Numer katalogowy: (USBIB0175-04H)
Producent: US Biological
Opis: Anti-BAX Rabbit Polyclonal Antibody
j.m.: 1 * 50 µl
Cena wymaga potwierdzenia u dostawcy
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Zapasy tego artykułu są ograniczone, ale możliwe, że jest on dostępny w pobliskim magazynie. Upewnij się, że jesteś zalogowany na stronie, aby móc sprawdzić dostępność zapasów. Jeśli call ciągle się wyświetla i potrzebujesz pomocy, zadzwoń na 58 323 82 00.
Ten produkt jest ograniczony w dostępie i można go zamówić tylko przy użyciu zaaprobowanego konta. Jeśli potrzebujesz pomocy, napisz do Działu Prawnego VWR na tomasz.chrobak@pl.vwr.com
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Produkt oryginalny został wycofany. Dostępny jest wskazny zamiennik .
Wybrany produkt został wycofany - sprzedaż do wyczerpania zapasów. Dostępne zamienniki można znaleźć poprzez wpisanie powyższego numeru katalogowego VWR w okno wyszukiwarki. Jeśli potrzebujesz dalszej pomocy, prosimy o kontakt z Działem Doradztwa Produktowego pod numerem telefonu 58 3238 220.
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