Wyszukano: 2-Oxa-6-azaspiro[3.4]octane

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6-Azaspiro[3.4]octan-2-ylmethanol

Producent: Apollo Scientific

Opis: 6-Azaspiro[3.4]octan-2-ylmethanol

2-Azaspiro[3.4]octane hemioxalate

Numer katalogowy: (APOSOR55128-1G)

Producent: Apollo Scientific

Opis: 2-Azaspiro[3.4]octane hemioxalate

j.m.: 1 * 1 g

Wyprzedaż

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1-Azaspiro[3.4]octan-2-one 95%

Producent: Apollo Scientific

Opis: 1-Azaspiro[3.4]octan-2-one 95%

2-Thia-6-azaspiro[3.4]octane 2,2-dioxide hemioxalate

Numer katalogowy: (APOSOR12645-100MG)

Producent: Apollo Scientific

Opis: 2-Thia-6-azaspiro[3.4]octane 2,2-dioxide hemioxalate

j.m.: 1 * 100 mg

Wyprzedaż

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2-Boc-6-hydroxy-2-azaspiro[3.4]octane

Numer katalogowy: (APOSOR317311-1G)

Producent: Apollo Scientific

Opis: 2-Boc-6-hydroxy-2-azaspiro[3.4]octane

j.m.: 1 * 1 g

Wyprzedaż

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(8S)-8-Amino-6-azaspiro[3.4]octan-5-one

Producent: Apollo Scientific

Opis: (8S)-8-Amino-6-azaspiro[3.4]octan-5-one

WYE-125132 ≥99% (by HPLC)

Producent: ENZO LIFE SCIENCES

Opis: Highly potent, ATP-competitive, and specific mTOR kinase inhibitor. Antiproliferative.

New Product

WYE-125132 ≥98%, crystalline solid

Producent: Cayman Chemical

Opis: WYE-125132 is an ATP-competitive inhibitor of mTOR (IC50 = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.