Wyszukano: Lejki do materia\u0142ów sypkich

Numer katalogowy: (ENZOADIOSA602E)

Producent: ENZO LIFE SCIENCES

Opis: Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex which regulates systemic, local and intracellular homeostatic responses elicited by hypoxia. HIF-1 is a heterodimer of HIF-1alpha and HIF-1beta. HIF-1beta is constitutively expressed and serves as a dimerization partner for several other transcription factors, while HIF-1alpha and the closely related HIF-2 are unique to HIF-1 and their expression is tightly regulated by cellular oxygen concentration. HIF-1 regulates a diverse group of genes, including erythropoietin, VEGF, glucose transporters, heme oxygenase, and NOS.

j.m.: 1 * 100 µG

New Product Wyprzedaż

Numer katalogowy: (ENZOADIOSA400E)

Producent: ENZO LIFE SCIENCES

Opis: Cleavage of heme b (Fe-protoporphyrin IX) at the a-methene carbon bridge to form the open tetrapyrrole, biliverdin IXa and carbon monoxide (CO) is catalyzed by heme oxygenase (HO) isozymes HO-1 and HO-2 (heme hydrogen-donor: oxygen oxidoreductase; EC 1.14.99.3). In mammalian species, biliverdin reductase (BVR; bilirubin: NAD(P)+ oxidoreductase; EC 1.3.1.24) converts the open tetrapyrrole to bilirubin. This pathway represents the only efficient way of making bilirubin and thereby deterring activation of oxygen by the heme molecule. HO-1 belongs to the heat shock protein family (Hsp32), while HO-2 takes a constitutive form expressed at exceedingly high levels in the brain and testes. The end products of the heme degradation process carry out important physiological activities. CO may act as a messenger in the brain and systemic organs stimulating cGMP-production through interactions with the heme-dependent form of guanylate cyclase. Bile pigments display potent antioxidant activity as well as effective antiviral activity against HIV and herpes virus. BVR is unique among all enzymes characterized to date in having two pH optima (6.8 and 8.7), using a different cofactor at each pH range (NADH at pH 7.0 and NADPH at pH 8.7). The enzyme displays pI and molecular mass microheterogeneity, apparently a result of post translational modifications. In rat, the enzyme also shows a tissue specific developmental pattern. BVR is not inactivated by heat shock, and its preexisting message is not sequestered from translation subsequent to thermal stress. Furthermore, reductase preserves microheterogeneity under thermal stress. BVR expression occurs not only in cells and brain regions that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. Rat cDNA for BVR has been isolated and characterized. The deduced protein contains 3 cysteine residues (Cys73, Cys281, and Cys290) involved in cofactor and substrate binding. Human BVR consists of a substantially longer polypeptide than the rat enzyme (41-42 kDa vs. 33 kDa), but also is dual cofactor and dual pH dependent, requires free SH groups for activity, and displays pI and molecular mass microheterogeneity. The human and rat BVR share some antigenic epitopes and show immunochemical cross reactivity.

j.m.: 1 * 100 µG

New Product Wyprzedaż

Numer katalogowy: (ENZOADIOSA150D)

Producent: ENZO LIFE SCIENCES

Opis: Anti-HMOX1 Rabbit Polyclonal Antibody

j.m.: 1 * 50 µG

New Product Wyprzedaż

Producent: ENZO LIFE SCIENCES

Opis: Anti-IgG1 Mouse Monoclonal Antibody [clone: MOPC-21]

New Product

Producent: Biotium

Opis: Highly cross-adsorbed donkey anti-mouse IgG (H L) secondary antibody labeled with our superior CF® dyes and other labels.

New Product

Numer katalogowy: (ENZOBPDABS039151)

Producent: ENZO LIFE SCIENCES

Opis: Anti-NGAL Mouse Monoclonal Antibody [clone: 15]

j.m.: 1 * 1 mg

New Product Wyprzedaż

Producent: ENZO LIFE SCIENCES

Opis: Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes alphaB-crystallin. It is characterized by a conserved C-terminal alpha-crystallin domain consisting of two anti-parallel beta-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-alpha, p70 S6K, PKD I, and PKC-delta. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.

New Product

Producent: ENZO LIFE SCIENCES

Opis: ERp57 (also known as Grp58), a member of the Thioredoxin superfamily, is an ER protein with disulfide isomerase activity. It has been shown to increase after oncogenic transformation and to be a component of the MHC Class I peptide-loading complex.

New Product

Numer katalogowy: (ENZOBMLAG60700100)

Producent: ENZO LIFE SCIENCES

Opis: Host: Mouse, Isotype: IgG1

j.m.: 1 * 100 µl

New Product Wyprzedaż

Numer katalogowy: (ENZOALX8049020100)

Producent: ENZO LIFE SCIENCES

Opis: Indoleamine 2,3-dioxygenase (IDO) is an IFN-γ inducible gene. It catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. IDO has been implicated to protect against intracellular and extracellular pathogens. . IDO1 is also known as Indolamine 2,3-dioxygenase, Indole 2,3-dioxygenase, and Indoleamine-pyrrole 2,3-dioxygenase. IDO is a ubiquitously expressed cytoplasmic protein with a predicted molecular weight of approximately 45 kDa. Indoleamine 2,3-dioxygenase (IDO) is one the best known IFN-γ inducible genes. The product of IDO gene catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. IDO has been implicated to protect against intracellular and extracellular pathogens. It also has been shown to maintain the special immune suppressive status of immune-privileged sites such as the brain, eyes, kidney, and placenta.

j.m.: 1 * 100 µG

New Product Wyprzedaż

Numer katalogowy: (ENZOALX805003AC100)

Producent: ENZO LIFE SCIENCES

Opis: Host: Mouse, Isotype: IgG1

j.m.: 1 * 100 µG

New Product Wyprzedaż

Numer katalogowy: (ENZOALX804844C100)

Producent: ENZO LIFE SCIENCES

Opis: Host: Mouse, Isotype: IgG1

j.m.: 1 * 100 µG

New Product Wyprzedaż

Numer katalogowy: (ENZOALX804864C100)

Producent: ENZO LIFE SCIENCES

Opis: Host: Mouse, Isotype: IgG1

j.m.: 1 * 100 µG

New Product Wyprzedaż

Producent: Biotium

Opis: Goat anti-mouse IgG (H+L), F(ab’)2 fragment secondary antibody labeled with CF®750 dye.

New Product

Producent: Biotium

Opis: This is a goat anti-mouse IgG (H L), F(ab’)2 fragment secondary antibody labeled with our superior CF® Dyes and other labels.

New Product

Producent: Biotium

Opis: Highly cross-adsorbed goat anti-guinea pig IgG (H L) secondary antibody labeled with our superior CF® Dyes.

New Product