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Rifampicyna, orange powder

Dostawca: MP Biomedicals
Uwaga

0219549005 02195490.1 02195490.2 0219549001 0219549025
ICNA0219549005EA 2110 PLN
ICNA0219549005 ICNA02195490.1 ICNA02195490.2 ICNA0219549001 ICNA0219549025
Rifampicyna, orange powder
Rifampicyna

Rifampin is a bactericidal antibiotic drug of the rifamycin group. It specifically inhibits DNA-dependent bacterial RNA Polymerase. Mammalian RNA polymerase is not affected.


It is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.


Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. It Inhibits the assembly of DNA and protein into mature virus particles. EmM (max absorbance, phosphate buffer,pH 7,38): 33,20 (237 nm); 32,10 (255 nm); 27,00 (334 nm);15,40 (475 nm)(Lit.). pKa (in water):1,7 (4-hydroxyl group), 7,9 (4-piperazine nitrogen); in methylcellosolve-water (4:1): 3,6 (4-hydroxyl group), 6,7 (3-piperazine nitrogen)(Lit.).


Soluble in chloroform(349 mg/ml, 25 °C), DMSO(~100 mg/ml), ethyl acetate(108 mg/ml, 25 °C), methanol(16 mg/ml, 25 °C) tetrahydrofuran.

Formuła: C₄₃H₅₈N₄O₁₂
Numer MDL: MFCD00151389
Numer CAS: 13292-46-1
Numer WE (dawny EINECS): 236-312-0
Klasyfikacja Merck : 12,08382

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Wyniki testów specyfikacyjnych

Synonyms Rifamycin AMP; Rifampicin; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV; Rifampicin
Form Orange Powder
Storage Store at +4 °C
Isoelectric Point 4,8 (in water) (Lit.)
Loss on Drying ≤2%
Optical Rotation [α]D25°=+10,6° (c=0,5% in CDCl3)(Lit.)


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