Pinometostat (EPZ-5676) ≥98%
Dostawca: Cayman Chemical
Synonim:
(2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(((cis-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol, Pinometostat
EPZ5676 is a highly potent aminonucleoside inhibitor of DOT1 l histone methyltransferase activity (Ki = 80 pM) that demonstrates 37000-fold selectivity over other methyltransferases.
It can selectively inhibit the proliferation of acute leukemia cell lines bearing MLL translocations (IC50s range from 3.5 nM - 1.3 µM).
Formuła:
C₃₀H₄₂N₈O₃ Temperatura przechowywania: Zamra·arka |
Numer MDL:
MFCD24849415 Numer CAS: 1380288-87-8 |
Wyniki testów specyfikacyjnych
Purity | ≥98% |
Formulation | A Crystalline Solid |
λmax | 255 nm |
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