Doramapimod ≥99% (by HPLC), Calbiochem®
Dostawca: Merck Millipore Calbiochem
p38 MAP kinase inhibitor X, BIRB 796, is a cell-permeable, highly potent, slow binding, high affinity inhibitor of p38a (IC50 = 8 and 97 nM with or without 2 h preincubation).
A cell-permeable pyrazolo-napthalenyl urea compound that acts as a highly potent, slowly binding (IC50 = 8 and 97 nM, respectively, against human p38α, respectively, with or without 2 h preincubation), but high affinity (t1/2 of dissociation from human p38α = 23 h), p38-selective inhibitor by simultaneously targeting the ATP-binding site and an adjacent DFG-out conformation-specific allosteric cavity. It inhibits JNK2α2 and c-Raf-1 only at much higher concentrations (IC50 = 98 nM and 1.4 µM, respectively) and displays little or no activity toward 10 other kinases (IC50 >20 µM). Shown to inhibit LPS-induced TNF-α production both in vitro (IC50 = 18 and 780 nM using THP-1 cells and in human whole blood, respectively) and in mice in vivo (by 84%; 30 mg/kg p.o.).
Formuła:
C₃₁H₃₇N₅O₃ MW: 527,669 g/mol Temperatura przechowywania: Lodówka |
Numer MDL:
MFCD09752957 Numer CAS: 285983-48-4 |
Wyniki testów specyfikacyjnych
Purity | ≥99% by HPLC |
Form | White Solid |
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