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Thapsigargin ≥97% (by TLC), colorless solid, Millipore®

Dostawca: Merck Millipore Calbiochem

586005-1EA 1310 PLN
586005-1
Thapsigargin ≥97% (by TLC), colorless solid, Millipore®
Thapsigargin

Thapsigargin is a cell-permeable tumour-promoting sesquiterpene lactone that releases Ca²⁺ by inhibiting endoplasmic reticular Ca²⁺-ATPase.


  • Colourless solid


It does not increase inositol phosphates and has no significant effect on protein kinase C. It increases Ca²⁺-dependent Na⁺ influx in human platelets in a dose-dependent manner. Ii induces apoptosis in rat thymocytes and in human hepatoma cells and in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation.

Formuła: C₃₄H₅₀O₁₂
MW: 650,762 g/mol
Temperatura przechowywania: Zamra·arka
Numer MDL: MFCD00083511
Numer CAS: 67526-95-8

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