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Metamizole 98, crystalline solid

Dostawca: Cayman Chemical

Synonim: (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methylamino)methanesulphonic acid sodium salt, Sulpyrine, Sodium (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methylamino)methanesulphonate, Metamizole sodium salt, Metamizole (sodium salt), Dipyrone

15771-25 15771-50
CAYM15771-25EA 368 PLN
CAYM15771-25 CAYM15771-50
Metamizole 98, crystalline solid
Metamizole

Metamizole (sodium salt) is a nonopioid prodrug that is rapidly hydrolyzed to the metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), which have analgesic and antipyretic effects. MAA has been shown to inhibit COX activity 8-9-fold more potently than AA (COX-1: IC50S= 2,6 and 20,8 µM, respectively, and COX-2: IC50S= 4,7 and 41,8 µM, respectively). These metabolites can be further acylated with arachidonic acid to form compounds that can bind to central and peripheral cannabinoid (CB1 and CB2) receptors and TRPV1 receptors at low micromolar concentrations.

Formuła: C₁₃H₁₆N₃O₄S·Na
MW: 333.3 g/mol
Temperatura przechowywania: Zamra·arka
Numer MDL: MFCD00020783
Numer CAS: 68-89-3

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