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3-Izobutylo-1-metyloksantyna, white powder

Dostawca: MP Biomedicals
Uwaga

02195262.1 02195262.2 0219526201 0219526205
ICNA02195262.1EA 275 PLN
ICNA02195262.1 ICNA02195262.2 ICNA0219526201 ICNA0219526205
3-Izobutylo-1-metyloksantyna, white powder

IBMX has been shown to be a potent, non-specific inhibitor of adenosine 3',5'-cyclic monophosphate phosphodiesterase (cAMP PDE)4, significantly more effective than theophylline. Also inhibits cGMP phosphodiesterases. IBMX inhibits cyclic nucleotide PDE with subsequent inhibition of cyclic nucleotide hydrolysis, resulting in accumulation of cyclic AMP and guanosine 3',5'-cyclic monophosphate.


IBMX helps in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1,3 μM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.


Soluble in Krebs-Henseleit bicarbonate buffer, ethanol (10 mg/ml or 25 mg/ml with sonication), DMSO (1 M with warming), or aqueous NaOH (pH 9,5); slightly soluble in water (0,3 mg/ml hot water). Solubility in 45% (w/v) aqueous 2-hydroxy-propyl-b-cyclodextrin is 3,2 mg/ml.


Uwaga: Research Use Only (RUO).

Formuła: C₁₀H₁₄N₄O₂
Temperatura przechowywania: Zamra·arka
Numer MDL: MFCD00005584
Numer CAS: 28822-58-4

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