Wyszukano: Białka

Producent: Shenandoah Biotechnology

Opis: IL-10 is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells.

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Producent: ENZO LIFE SCIENCES

Opis: MG-132 is a potent, cell permeable and selective proteasome inhibitor (Ki = 4 nM).1 It inhibits NF-κB activation by preventing IκB degradation (IC50 = 3 μM). The peptide blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1 μM MG-132, 2 h.). It also stimulates neurite outgrowth in PC12 cells (20 nM optimal). The peptide has also been reported to increase the survival rate of mesenchymal stem cells following their transplantation. IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0,85 and 0,1 μM respectively. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-132 activates autophagy.

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Producent: Shenandoah Biotechnology

Opis: Neutrophil activating peptide 2 (NAP-2), also known as CXCL7, is a member of the CXC family of chemokines. NAP-2 is a carboxyl-terminal fragment produced by proteolytic cleavage of the platelet basic protein (PBP). NAP-2 is released from platelets and binds to the receptors CXCR1 and CXCR2 to chemoattract and activate neutrophils during inflammatory events.

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Producent: Shenandoah Biotechnology

Opis: B cell-attracting chemokine 1 (BCA-1), also known as CXCL13, is expressed at high levels in lymphoid tissues, such as the spleen, lymph nodes, and Peyer's patches.  BCA-1 activates signaling through the receptor Burkitt lymphoma receptor 1 (BLR1) to chemoattract B cells.

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Numer katalogowy: (ENZOBMLAW94850100)

Producent: ENZO LIFE SCIENCES

Opis: Highly specific aldehyde based inhibitor of the caspase-like peptidic activity of the 20S proteasome.

j.m.: 1 * 100 µG

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Numer katalogowy: (PRSI92-248)

Producent: ProSci Inc.

Opis: Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.

j.m.: 1 * 0,05 mg

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Numer katalogowy: (PRSI96-655)

Producent: ProSci Inc.

Opis: Protein G is an immunoglobulin-binding protein expressed in group C and G Streptococcal bacteria much like Protein A but with differing specificities. It is a 65-kDa (G148 protein G) and a 58 kDa (C40 protein G) cell surface protein that has found application in purifying antibodies through its binding to the Fc region. The native molecule also binds albumin, however, because serum albumin is a major contaminant of antibody sources, the albumin binding site has been removed from this recombinant form of Protein G.

j.m.: 1 * 2 mg

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Numer katalogowy: (PRSI91-088)

Producent: ProSci Inc.

Opis: Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

j.m.: 1 * 0,05 mg

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Numer katalogowy: (PRSI91-838)

Producent: ProSci Inc.

Opis: ADAM DEC1 protein is expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. ADAM DEC1 is induced during DC maturation and up-regulated in response to T-cell signals. It may play an important role in the control of the immune response and during pregnancy.

j.m.: 1 * 0,05 mg

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Numer katalogowy: (ORIGTP313207M)

Producent: OriGene

Opis: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation.

j.m.: 1 * 100 µl

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Numer katalogowy: (ORIGTP307512)

Producent: OriGene

Opis: This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants.

j.m.: 1 * 20 µG

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Numer katalogowy: (ENZOENZACC1050200)

Producent: ENZO LIFE SCIENCES

Opis: The HIGHDEF® DAB Chromogen/Substrate Set can be used in conjunction with peroxidase-based immunostaining systems. Peroxidase from the antibody detection system reacts with hydrogen peroxide substrate to degrade it, which then reacts with DAB, precipitating it at positive sites and yielding a dark brown color.

j.m.: 1 * 200 mL

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Numer katalogowy: (ENZOBMLAM1000001)

Producent: ENZO LIFE SCIENCES

Opis: Integrin αvβ3 antagonist. Inhibits cell adhesion events mediated by αvβ3. Inhibits angiogenesis. Induces rapid regression of histologically distinct human tumors. Induces apoptosis of angiogenic blood vessels.

j.m.: 1 * 1 mg

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Producent: ENZO LIFE SCIENCES

Opis: Caspase-6 inhibitor

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Numer katalogowy: (ENZOBMLSE4620100)

Producent: ENZO LIFE SCIENCES

Opis: Produced in Sf9 cells. Recombinant human MKP-2 fused at the N-terminus to a His-tag.

j.m.: 1 * 100 µG

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Numer katalogowy: (ENZOBMLSE4130005)

Producent: ENZO LIFE SCIENCES

Opis: Produced in insect cells.

j.m.: 1 * 5 µG

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